Gut Microbiota Metagenomics for Chronic Liver Disease
Active, not recruiting
- Conditions
- Liver Disease Chronic
- Registration Number
- NCT04339725
- Lead Sponsor
- Chuncheon Sacred Heart Hospital
- Brief Summary
Gut microbiota modulation has effect on chronic liver disease
- Detailed Description
Chronic liver disease has been known as a disease of the liver which lasts over a period of 6-month. It consists of inflammation, hepatitis, cirrhosis, hepatocellular carcinoma.
Gut microbiota plays an important roles in the chronic liver disease. It can suppress the progression of the liver disease by moulation gut microbiota.
The investigators are still evaluating the effect of gut microbiota on the liver disease.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 3240
Inclusion Criteria
- Age 19+
- Normal : AST or ALT level < 50IU/L, BMI < 25
- Liver disease : AST or ATL level ≥ 50IU/L, BMI ≥ 25
- Patients hospitalized with chronic liver disease (viral hepatitis, alcoholic liver disease, non-alcoholic liver disease, cirrhosis, liver cancer)
Exclusion Criteria
- Normal : AST or ATL level ≥ 50IU/L, BMI ≥ 25
- Liver disease : AST or ALT level < 50IU/L, BMI < 25
- If the patient refuses
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Liver enzyme 10 years Compare the liver enzyme level
Fecal DNA 10 years Compare the species and proportions of the gut microbiome
BMI 10 years Compare the body mass index
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital
🇰🇷Chuncheon, Korea, Republic of
Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital🇰🇷Chuncheon, Korea, Republic of