Evaluation of Aqueous Humor DEL-1 and IL-17 Levels in Diabetic Cataract Patients
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- DEL-1 and IL-17 levels
研究概览
简要总结
By comparing DEL-1 and IL-17 levels in the aqueous humor of diabetic cataract patients with the aqueous humor of non-diabetic patients, we aim to understand the biochemical effects of diabetes-related inflammatory processes in the eye.
详细描述
Developmental Endothelial Locus-1 (DEL-1) is a molecule related to endothelial cells and is a protein involved in intercellular interactions. It is generally associated with the development and function of endothelial cells lining the inner surface of the vessel. It plays an important role in the regulation of inflammation, the development of vessels and the organization of endothelial cells. It has also been shown to be associated with some types of cancer. It may also be effective in tissue regeneration and healing of injuries.
IL-17 (Interleukin-17) is a group of cytokines that play an important role in the immune system. There are several subtypes of IL-17, the best known and most researched being IL-17A. It regulates the body's immune response to certain infections. It is an important cytokine that initiates and supports the inflammation process. IL-17 plays an important role in the pathogenesis of various autoimmune and inflammatory diseases.
DEL-1 and IL-17 are two different molecules that act on inflammation and immune responses. DEL-1 helps regulate inflammation by protecting vascular health, while IL-17 can accelerate the course of diseases by increasing inflammation.
Diabetes is a systemic disease associated with oxidative stress and chronic inflammation. Retinopathy, cataract and glaucoma diseases develop due to diabetes. DEL-1 is a protein involved in the maintenance of vascular homeostasis and regulation of inflammation. Since diabetic patients have chronic inflammation and microvascular dysfunction, changes in DEL-1 levels may provide important clues to the pathophysiology
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Screening
- 盲法
- Single (Outcomes Assessor)
盲法说明
During the statistical analysis, the data analyst can analyze only "Group A" and "Group B" without knowing the group names. After the results are obtained, the groups are opened.
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Cataract diagnosed and surgery planned
- •Patients without any other ocular pathology other than cataract.
- •Type 2 DM for at least 5 years in the diabetic group
排除标准
- •Patients with previous intraocular surgery
- •Those with inflammatory eye diseases (e.g. uveitis)
- •Those with autoimmune diseases or systemic inflammatory diseases
- •Those receiving local or systemic steroid therapy
- •Those with severe systemic disease (e.g. advanced renal failure, malignancy)
研究组 & 干预措施
Diabetic cataract patients
Collection of aqueous humor during cataract surgery in non-diabetic patients and study of DEL1 and IL 17
干预措施: Del 1 (Diagnostic Test)
Diabetic cataract patients
Collection of aqueous humor during cataract surgery in non-diabetic patients and study of DEL1 and IL 17
干预措施: IL 17 (Diagnostic Test)
Non-diabetic cataract patients
Collection of aqueous humor during cataract surgery in non-diabetic patients and study of DEL1 and IL 17
干预措施: Del 1 (Diagnostic Test)
Non-diabetic cataract patients
Collection of aqueous humor during cataract surgery in non-diabetic patients and study of DEL1 and IL 17
干预措施: IL 17 (Diagnostic Test)
结局指标
主要结局
DEL-1 and IL-17 levels
时间窗: Perioperative
To be measured quantitatively with ELISA kits, pg/mL
次要结局
- Correlation between DEL-1 and IL-17(Perioperative)
- Association of biomarker levels with HbA1c(Perioperative)
- Impact of demographic factors(Baseline)
研究者
Suzan Dogruya
Assistant professor
Uşak University