Comparison of clinical outcome in dry eye treatment between corneal epithelial thickness assessment with spectral domain optical coherence tomography and clinical assessment
Phase 2
Recruiting
- Conditions
- Corneal epithelial thickness measured by spectral domain optical coherence tomography can use for grading dry eye severity and have effect on treatment efficacyCorneal epithelial thickness, spectral domain optical coherence tomography, dry eye disease
- Registration Number
- TCTR20210706006
- Lead Sponsor
- /A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 92
Inclusion Criteria
Participant diagnosed Dry eye by TFOS DEWS II criteria
- DEQ-5 Questionnaire not less than 6 with one of the followings
- Non-invasive Tears film break up time < 10 second
- Ocular surface staining at cornea >5 spot or conjunctiva > 9 spot or eyelid staining length not less than 2 mm and not less than 25 % width
Exclusion Criteria
-other ocular surface disease eg. Epithelial basement membrane dystrophy, Corneal scar, Herpes infection, Recurrent corneal erosion
-eyelid or blinking problem
-other ocular medication eg. glaucoma medication
-contact lens wear
-systemic medication eg.Anti-histamine, Estrogen replacement therapy, Anti-depressant, Isotretinoin
-history of ocular trauma or ocular surgery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Eye dryness at 1 and 3 month after dry eye treatment Tear film break up time
- Secondary Outcome Measures
Name Time Method Eye dryness at 1 and 3 month after dry eye treatment DEQ-5 score,Eye dryness at 1 and 3 month after dry eye treatment Corneal fluorescein stain grading