Effect of Heat Stress on Global LV Function in Anesthetized Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Change in ejection fraction before and after hyperthermia
研究概览
简要总结
Recent data suggests that increased temperature improves inotropic function during systole and may improve diastolic function in healthy humans at rest, despite a reduction in left ventricular volume at end diastole. The effect of heat stress has not been reported in patients receiving general anesthesia and the impact of general anesthesia on these findings is not known. Trans-esophageal echocardiography will be used to measure parameters important to both systolic and diastolic function at temperature intervals of 1°C in patients undergoing "Heated Intraoperative Peritoneal Chemotherapy" (HIPEC.) That general anesthesia will not alter the cardiovascular effects of increased temperature that has been reported in healthy, un-anesthetized humans is the hypothesis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •any patient presenting for hyperthermic intraperitoneal chemotherapy.
排除标准
- •Subjects less than 18 years old.
- •pregnant women
- •prisoners,
- •institutionalized individuals
- •Any patient with known contraindication to Transesophageal echocardiography.
- •Patients with known cardiac dysfunction prior to screening will be excluded.
结局指标
主要结局
Change in ejection fraction before and after hyperthermia
时间窗: Approximately 6 hours from prior to hyperthermia to during hyperthermia.
次要结局
- Transmitral inflow velocities before and after hyperthermia(Approximately 6 hours from prior to hyperthermia to during hyperthermia.)
- Pulmonary venous inflow velocities before and during hyperthermia(Approximately 6 hours from prior to hyperthermia to during hyperthermia.)
- Mitral annular tissue doppler velocities before and during hyperthermia(Approximately 6 hours from prior to hyperthermia to during hyperthermia.)
研究者
Edward O'Brien
Associate Professor of Anesthesiology
University of California, San Diego