Influence of Intra-Canal Cryotherapy on Post-Endodontic Pain and Interleukin-6 Expression Using Different Irrigation Protocols: A Randomized Clinical Trial

Suez Canal University1 site in 1 country48 target enrollmentDecember 1, 2017

ConditionsSymptomatic Periapical Periodontitis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Symptomatic Periapical Periodontitis
Sponsor: Suez Canal University
Enrollment: 48
Locations: 1
Primary Endpoint: PAIN
Status: Completed
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

the study was to evaluate the effect of intra-canal cryotherapy on post-endodontic pain and interleukin-6 expression in teeth with symptomatic apical periodontitis using different irrigation protocols.

Registry

clinicaltrials.gov

Start Date

December 1, 2017

End Date

October 9, 2018

Last Updated

6 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Suez Canal University

Responsible Party

Principal Investigator

Ahmed Emad

principal investigator

Suez Canal University

Eligibility Criteria

Inclusion Criteria

•Anterior or premolar single canal in single rooted teeth.
•Patients aged 20 to 50 years.

Exclusion Criteria

•Patients under anti-inflammatory medication, immune-suppressive chemotherapy or any antibiotic medication for the last 2 months.
•Pregnant or lactating females.
•Teeth with endo-perio lesions.

Outcomes

Primary Outcomes

PAIN

Time Frame: one week

post-operative pain is measured by using visual analogue scale (VAS) The modified VAS will include a 10 cm straight horizontal line numbered at each centimeter with following criteria: (0) for no pain, (1-3) for mild pain, (4-6) for moderate pain, (7-9) for severe tolerable pain and (10) for severe intolerable pain