Study of secondary infections causing micro-organisms associated with Scabies

Not Applicable

• Conditions: Health Condition 1: L088- Other specified local infections of the skin and subcutaneous tissue

• Registration Number: CTRI/2022/01/039534
• Lead Sponsor: Dioraphte

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 February 2022

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Inclusion criteria for patients: Aged > 6 months old with clinically suspected Scabies.

Inclusion criteria for controls: Healthy volunteers with no scabies or history of scabies and > 18 years of age

Exclusion Criteria

Exclusion criteria for patients and controls: unclear diagnosis, other skin parasites, other skin condition, history of chronic dermatologic disease, treatment for scabies within 7 days, antibiotic treatment within the last month.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The results generated will determine the diversity and dynamics of microbes associated with human scabies at a range of geographical and economical settings, which will result in the first comprehensive global snapshot of this disease complex. Longitudinal data across multiple time points through treatment will inform about treatment efficiency and provide insights into correlation-versus- causation questions. Through in depth transcriptomics/proteomics we hope to identify the molecular mechanisms underpinning the synergy between mites and bacteria, and how they work together to deal with the host defence. In summary, this project will provide baseline molecular data for translational research into improved treatment and management strategies, to ultimately better scabies disease outcomes globally.Timepoint: 4 years

Secondary Outcome Measures

Name	Time	Method
ongitudinal data across multiple time points through treatment will inform about treatment efficiency and provide insights into correlation-versus- causation questions. Through in depth transcriptomics/proteomics we hope to identify the molecular mechanisms underpinning the synergy between mites and bacteria, and how they work together to deal with the host defence. In summary, this project will provide baseline molecular data for translational research into improved treatment and management strategies, to ultimately better scabies disease outcomes globally.Timepoint: 4 years