IJzerstapeling bij patiënten met MDS: De waarde van nieuwe ijzerparameters en MRI als voorspeller van ijzerstapeling.

Recruiting

• Conditions: Myelodysplastic syndrome (MDS)

• Registration Number: NL-OMON27359
• Lead Sponsor: niversity Medical Centre NIjmegenDepartmetn of Hematology

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 75

Inclusion Criteria

1. Patients with MDS according to WHO 2001-criteria (RA, RARS, RAEB-1, RAEB-2, RCMD, RCMD-RS, MDS with isolated del(5q), MDS-U);

2. Patient with IPSS low-risk, intermediate-1 or intermediate-2 risk;

Exclusion Criteria

1. Patients with previous intensive anti-leukemic therapy (intensive chemotherapy and/or stem cell transplantation);

2. Patients with secondary or therapy-related AML and MDS after chemotherapy for a malignancy or radiotherapy;

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
A relationship between T2*Liver and or T2*Heart levels and the number of blood transfusions.

Secondary Outcome Measures

Name	Time	Method
Evidence for iron overload in transfusion-independent and transfusion-dependent MDS patients due to ineffective erythropoiesis.