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Effect of Intermittent Versus Continuous Energy Restriction on Compensatory Mechanisms Activated During Weight Reduction

Not Applicable
Completed
Conditions
Obesity
Registration Number
NCT02169778
Lead Sponsor
Norwegian University of Science and Technology
Brief Summary

Obesity has become a global epidemic with huge public health implications. Although clinical significant weight loss can be achieved by a combination of diet and behavioral modification, strong metabolic adaptations, with increased appetite and suppressed energy expenditure, are activated, which compromise weight loss maintenance and increase the risk of relapse. The aim of this project is to compare the effects of intermittent versus continuous energy restriction on the compensatory responses previously described using two low calory diets, with a similar macronutrient distribution. More specifically, this study will analyze, in the short-term, if an intermittent energy restricted diet is associated with less appetite and low reduction in energy expenditure when compared with a continuous energy restricted diet. This project can bring large practical benefits concerning the design of weight loss programs to minimize weight relapse.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
34
Inclusion Criteria
  • adult (18-50 years old)
  • obese healthy volunteers (30<BMI<40 kg/m2)
  • weight stable on the last three months (<2kg), not currently dieting to lose weight and with an inactive lifestyle
Exclusion Criteria
  • history of endocrine/cardiovascular/pulmonary/kidney disease
  • anaemia
  • milk intolerance
  • depression or other psychological disorders
  • eating disorders
  • drug or alcohol abuse within the last two years
  • current medication known to affect appetite or induce weight loss
  • a planned surgery during the study period
  • participating in another research study

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
Appetite related hormones12 weeks after the intervention

Appetite-related hormones (active Ghrelin, PYY, GLP-1, CCK) will be measured in fasting and every 30 minutes up to 2,5 hours.

Secondary Outcome Measures
NameTimeMethod
Body compositionAt 1 year from baseline

RMR measured by indirect calorimetry

Resting metabolic rate (RMR)12 weeks after the intervention

RMR measured by indirect calorimetry

Exercise efficiency12 weeks after the intervention

Exercise efficiency measured by graded exercise on a bike

Trial Locations

Locations (1)

Norwegian University of Science and Technology

🇳🇴

Trondheim, Norway

Norwegian University of Science and Technology
🇳🇴Trondheim, Norway

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