Effect of Intermittent Versus Continuous Energy Restriction on Compensatory Mechanisms Activated During Weight Reduction

Not Applicable

Completed

• Conditions: Obesity

• Registration Number: NCT02169778
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

Obesity has become a global epidemic with huge public health implications. Although clinical significant weight loss can be achieved by a combination of diet and behavioral modification, strong metabolic adaptations, with increased appetite and suppressed energy expenditure, are activated, which compromise weight loss maintenance and increase the risk of relapse. The aim of this project is to compare the effects of intermittent versus continuous energy restriction on the compensatory responses previously described using two low calory diets, with a similar macronutrient distribution. More specifically, this study will analyze, in the short-term, if an intermittent energy restricted diet is associated with less appetite and low reduction in energy expenditure when compared with a continuous energy restricted diet. This project can bring large practical benefits concerning the design of weight loss programs to minimize weight relapse.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-08
• Study First Submitted: 2014-06-17
• Study First Submitted QC: 2014-06-19
• Study First Posted: 2014-06-23
• Primary Completion: 2014-12
• Study Completion: 2015-12
• Status Verified: 2017-04
• Last Update Submitted: 2017-04-28
• Last Update Posted: 2017-05-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• adult (18-50 years old)
• obese healthy volunteers (30<BMI<40 kg/m2)
• weight stable on the last three months (<2kg), not currently dieting to lose weight and with an inactive lifestyle

Exclusion Criteria

• history of endocrine/cardiovascular/pulmonary/kidney disease
• anaemia
• milk intolerance
• depression or other psychological disorders
• eating disorders
• drug or alcohol abuse within the last two years
• current medication known to affect appetite or induce weight loss
• a planned surgery during the study period
• participating in another research study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Appetite related hormones	12 weeks after the intervention	Appetite-related hormones (active Ghrelin, PYY, GLP-1, CCK) will be measured in fasting and every 30 minutes up to 2,5 hours.

Secondary Outcome Measures

Name	Time	Method
Body composition	At 1 year from baseline	RMR measured by indirect calorimetry
Resting metabolic rate (RMR)	12 weeks after the intervention	RMR measured by indirect calorimetry
Exercise efficiency	12 weeks after the intervention	Exercise efficiency measured by graded exercise on a bike

Trial Locations

Locations (1)

Norwegian University of Science and Technology; 🇳🇴 Trondheim, Norway