跳至主要内容
临床试验/NCT05546086
NCT05546086招募中不适用

Risk Prediction System for Metabolic Associated Fatty Liver Disease, a Community-based Cohort Study

Beijing Friendship Hospital1 个研究点 分布在 1 个国家目标入组 8,103 人开始时间: 2022年4月18日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
8,103
试验地点
1
主要终点
Cardiovascular disease

研究概览

简要总结

Metabolic associated fatty liver disease(MEFLD) is a major chronic liver disease that can lead to various adverse events, such as liver cancer, cardiovascular disease, and chronic kidney disease. The present community-based cohort study enrolls subjects who take health physical examinations at the sub-center outpatient department, Beijing Friendship Hospital. Investigators collect their baseline information, including demographic data, clinical history, physical examination, laboratory results, imageological examination, and so on. Follow-up surveys are conducted annually and the information collected is the same as the baseline. The outcome information, including cardiovascular disease, malignancy, liver cirrhosis, liver decompensation, liver transplantation, and all-cause mortality, are obtained by linking to the hospital discharge database and death registration system of Beijing. The primary aim of the study is to build a risk-stratified evaluation system for MAFLD through the cohort.

详细描述

The present community-based cohort study enrolls subjects who take physical health examinations at the sub-center outpatient department, Beijing Friendship Hospital. After signing the informed consent, Their previous health physical examination results, which were recorded in the Hospital Information System (HIS) are collected retrospectively. Then, Investigators collect their baseline information, including demographic data, clinical history, physical examination, laboratory results, image logical examination, and so on. Additionally, follow-up surveys will be conducted annually and the information collected is the same as the baseline. The outcome information, including cardiovascular disease, malignancy, liver cirrhosis, liver decompensation, liver transplantation, and all-cause mortality, is obtained from the hospital discharge database and death registration system in Beijing. The study's primary aim is to build a risk-stratified evaluation system for MAFLD through a community population cohort with long-term stable follow-up.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Aged 18 years or older
  • Permanent residents in Beijing
  • Signing informed consent

排除标准

  • 未提供

结局指标

主要结局

Cardiovascular disease

时间窗: 1 to 10 years

Incidence of cardiovascular disease during follow-ups

次要结局

  • All-cause mortality(1 to 10 years)
  • Malignancy(1 to 10 years)
  • Liver cirrhosis(1 to 10 years)
  • Liver decompensation(1 to 10 years)
  • Liver transplantation(1 to 10 years)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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