Can we reduce asthma attacks in children using exhaled nitric oxide measurements?

Not Applicable

Completed

• Conditions: Asthma; Respiratory

• Registration Number: ISRCTN67875351
• Lead Sponsor: niversity of Aberdeen and NHS Grampian

Brief Summary

2019 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/31585544 protocol (added 07/10/2019) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35101183/ (added 02/02/2022) 2023 Other publications in https://pubmed.ncbi.nlm.nih.gov/36603013/ Qualitative process evaluation (added 07/06/2023) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35679443/ (added 07/06/2023) 2024 Other publications in https://pubmed.ncbi.nlm.nih.gov/38802171/ Cost analysis (added 28/05/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2017-04-12
• Study Completion: 2021-01-31
• Last Update Posted: 10 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 515

Inclusion Criteria

1. Asthma diagnosed or confirmed by consultant paediatrician (or Read code for asthma if recruited in primary care)
2. Aged 6 years or older and not yet reached the date of their 16th birthday
3. Currently prescribed inhaled corticosteroids (<1000mcg budesonide equivalent per day in those <12 years; <2000 mcg budesonide equivalent per day for older children)
4. At least one patient/parent reported-asthma exacerbation treated with oral corticosteroids in the 12 months prior to recruitment

Exclusion Criteria

1. Unable to provide FeNO measurement at baseline assessment (expected prevalence <5%)
2. Other chronic respiratory conditions which also have exacerbations
3. Current treatment with maintenance oral steroids

Study & Design

• Study Type: Interventional
• Study Design: Not specified