Adenosine Administration during and after Primary percutaneous coronary intervention in acute myocardial infarction – a Randomized Controlled Trial (ADAPT).
Completed
- Conditions
- 1. Percutaneous coronary intervention<br />2. Myocardial infarction<br /> 3. Reperfusion therapy.
- Registration Number
- NL-OMON22898
- Lead Sponsor
- niversity Medical Center Groningen, <br>Thoraxcenter, Dept Cardiology.
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 450
Inclusion Criteria
1. A diagnosis of acute MI defined by chest pain suggestive for myocardial ischemia for at least 30 minutes, with a time from onset of symptoms of less than 12 hours, before hospital admission.
2. An ECG with ST- segment deviation of more than 0.1 mV in 2 or more leads.
Exclusion Criteria
1. Need for emergency coronary artery bypass grafting (CABG).
2. Presence of cardiogenic shock.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Residual ST-segment deviation at 30 to 60 minutes after the procedure.
- Secondary Outcome Measures
Name Time Method 1. Myocardial blush grade;<br /> <br>2. ST-segment deviation resolution;<br /><br>3. Enzymatic infarct size;<br /> <br>4. Distal embolization on coronary angiography;<br /> <br>5. Post-procedural TIMI flow;<br /> <br>6. Clinical outcome at 30 days and 12 months.