Impact of long-lasting insecticide treated bednets with and without piperonyl butoxide (PBO) on malaria indicators in Uganda

Not Applicable

Completed

• Conditions: Malaria; Infections and Infestations

• Registration Number: ISRCTN17516395
• Lead Sponsor: iverpool School of Tropical Medicine

Brief Summary

2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/30424775 baseline results 2019 Results article in https://www.ncbi.nlm.nih.gov/pubmed/30867018 baseline results (added 15/03/2019) 2019 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/31159887 protocol (added 05/06/2019) 2019 Results article in https://www.ncbi.nlm.nih.gov/pubmed/31234882 provisional results (added 22/10/2019) 2020 Results article in https://www.ncbi.nlm.nih.gov/pubmed/32305094 results (added 21/04/2020) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/36174592/ final results (added 30/09/2022) 2024 Results article in https://pubmed.ncbi.nlm.nih.gov/38914669/ (added 25/06/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2017-02-14
• Study Completion: 2020-12-31
• Last Update Posted: 8 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 38751

Inclusion Criteria

Household inclusion criteria:
1. At least one household resident between 2-10 years of age present (with an adult caregiver willing to provide informed consent for the clinical survey)
2. At least one adult aged 18 years or older present
3. Adult is a usual resident who slept in the sampled household on the night before the survey
4. Agreement of the adult resident to provide informed consent for the household survey

Children inclusion criteria:
1. Child aged 5 years and over
2. Usual resident who was present in the sampled household on the night before the survey
3. Agreement of parent/guardian to provide informed consent
4. Agreement of child aged 8 years or older to provide assent

Exclusion Criteria

Household exclusion criteria:
1. Dwelling destroyed or not found
2. Household vacant
3. No adult resident home on more than 3 occasions

Children exclusion criteria:
Child not home on day of survey

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Parasite prevalence (defined as the proportion of thick blood smears that are positive for asexual parasites) in children aged 2-10 years is assessed using cross-sectional surveys at baseline (prior to distribution of the nets) and up to 3 times after nets are distributed, 6, 12 and 18-24 months after distribution.