The Contribution of Stressful Life Events and Insufficient Sleep to Reward-Related Brain Function and Depression in Adolescent Girls
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Reward-related brain function
研究概览
简要总结
This study evaluates whether increasing sleep duration can increase neural and behavioral response to rewards and decrease depressive symptoms in 18- to 22-year-old women with insufficient sleep and depressive symptoms.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 22 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Insufficient sleep (total sleep time < 8 hours per night, with sleepiness scores ≥ 6 on the Epworth Sleepiness Scale OR ≥ 16 on the PROMIS Sleep Related Impairment Scale)
- •Symptoms of depression (≥ 15 on the Center for Epidemiological Studies for Depression Scale)
排除标准
- •Current insomnia, hypersomnia, sleep disordered breathing, sleep movement disorder, or circadian rhythm disorder
- •History of head injury with loss of consciousness within the past two years
- •History of head injury with loss of consciousness two or more years ago and meet criteria for post concussion syndrome
- •Neurological disorder
- •Use of psychiatric medications
- •Current psychotic symptoms
- •Active suicidal ideation
- •Conditions that are contraindicated for MRI (e.g., ferromagnetic material in the body)
- •Meet criteria for current substance use disorder with greater than mild severity
结局指标
主要结局
Reward-related brain function
时间窗: 1 week
BOLD fMRI response during Reward Guessing Task
Sleep duration
时间窗: 1 week
Mean actigraphy-measured sleep duration
Depressive symptoms
时间窗: 1 week
Center for Epidemiological Studies Depression Scale score. The CESD-R is a 20-item measure of the frequency of depressive symptoms, with each item rated on a scale from 0 (not at all or less than one day) to 5 (nearly every day). Total scores range from 0 to 100, with higher scores indicating greater number and frequency of depressive symptoms.
次要结局
- Reward effort(1 week)
- Positive affect(1 week)
- Negative affect(1 week)
- Reward-related functional connectivity(1 week)
研究者
Melynda Casement
Assistant Professor
University of Oregon