NCT00566423CompletedNot Applicable
Biomarkers in the Diagnosis and Assessment of PAH
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Northwell Health
- Enrollment
- 75
- Locations
- 1
- Primary Endpoint
- Assess the correlation of plasma/arterial BNP and MIF levels pre/post with the 6 Minute walk test distance and echocardiographic parameters as surrogate markers of severity of PAH.
Study Overview
Brief Summary
The investigators hypothesize that baseline plasma brain natriuretic peptide (BNP) and migration inhibitory factor (MIF) levels are surrogate markers of clinical severity of PAH and that changes in plasma brain natriuretic peptide (BNP) and MIF levels pre and post exercise.
Detailed Description
As above
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Confirmed diagnosis of PAH, based on currently accepted gold standard for Right Heart Catheterization.
- •Patients with mean artery pressure of greater that 25 mm Hg at rest or 30mm Hg during exercise with pulmonary capillary wedge pressure less than 18mm Hg on right heart catheterization.
Exclusion Criteria
- •Significant left heart disease or renal insufficiency (serum creatinine > 1.5 mg%).
Arms & Interventions
1
Experimental
Patients with Pulmonary Arterial Hypertension
Intervention: Blood draw (Other)
Outcomes
Primary Outcomes
Assess the correlation of plasma/arterial BNP and MIF levels pre/post with the 6 Minute walk test distance and echocardiographic parameters as surrogate markers of severity of PAH.
Time Frame: 2 year
Secondary Outcomes
- To determine if changes in plasma/arterial MIF levels pre/post 6MW test are due to MIF released from the lungs(2 year)
Investigators
Study Sites (1)
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