Prostate Cancer localization with a Multiparametric MR Approach - PCa-MAP

Recruiting

Conditions: to localize prostate cancer within the prostate
10036958

Registration Number: NL-OMON33366

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

• Patients with biopsy-proven diagnosis of adenocarcinoma of the prostate
• Radical prostatectomy and histopathological exam planned

Exclusion Criteria

• Patients who are unable to undergo an MR exam, including subjects with contra-indications to MR exams
• Therapy or surgical procedure applied to the prostate or to other organs in vicinity to the prostat

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To determine the diagnostic accuracy (area under the receiver-operating<br /><br>characteristic curve) of 3-Tesla multi-modality non-endorectal coil (ERC) MR<br /><br>imaging in localizing prostate cancer, by correlating:<br /><br>a) focal areas of low signal intensity on T2-weighted images;<br /><br>b) the extent and degree of deviating metabolite ratios derived from MRSI. This<br /><br>can be the choline+creatine/citrate ratio or if possible, the choline / citrate<br /><br>ratio;<br /><br>c) the extent and degree of apparent diffusion coefficient reduction on DWI;<br /><br>d) the extent and degree of perfusion abnormality on DCE-MRI;<br /><br>with the presence or absence of cancer at (reconstructed) whole mount section<br /><br>histopathology.<br /><br><br /><br>Hypothesis: 3-Tesla multi-modality non-ERC MR will localize prostate cancer<br /><br>with an accuracy of 85%.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Proving that multi-modality MR data allows for predicting tumor grade.<br /><br>The parameters from the different MR methods for a tumor focus can be<br /><br>correlated to the local Gleason grade of the corresponding lesion in the<br /><br>histopathological specimens. </p><br>