Midazolam, propofol used alone or sequentially for long-term sedation in critically ill, mechanically ventilated patients
Not Applicable
Completed
- Conditions
- Mechanical ventilationNot Applicable
- Registration Number
- ISRCTN01173443
- Lead Sponsor
- West China Hospital of Sichuan University (China)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 105
Inclusion Criteria
Intubated patients (>18 years old) who were expected to receive long-term (>3 days) mechanical ventilation on admission to the ICU within West China Hospital of Sichuan University between March 2009 and September 2011
Exclusion Criteria
1. Known or suspected allergy to propofol or midazolam
2. Suspected pregnancy
3. Gross obesity
4. Hyperlipemia
5. Moribund state
6. History of alcoholism or intake of anti-anxiety drugs or hypnotics
7. Chronic renal failure
8. Coma by cranial trauma or neurosurgery or unknown etiology or status epilepticus
9. Unwillingness to provide informed consent by patients or their authorized surrogates following ICU admission
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the recovery and extubation time, which were defined as the time from the cessation of sedation until awakening and extubation
- Secondary Outcome Measures
Name Time Method To determine the cost of sedation, the primary monetary pharmaceutical costs of sedation and total ICU costs (including ICU therapy and sedation) were calculated. After patients were transferred out of ICU, their recollection of mechanical ventilation-related events (rolling over, suction, and endotracheal tube stimulation and pain) were recorded using a questionnaire. The patients responded from the following options: (A) unbearable memory, (B) bearable memory, and (C) no memory.