Does Vitamin D Deficiency Associated With Hypercoagulability & Increased Thrombin Generation?

Completed

• Conditions: Chest Pain

• Registration Number: NCT01799655
• Lead Sponsor: HaEmek Medical Center, Israel

Brief Summary

Cardiovascular disease is the most common cause of mortality and morbidity worldwide. Recently, a growing body of evidence has identified Vitamin D deficiency as a potential risk factor for cardiovascular disease. Therefore, there is an increasing interest to explore the mechanism in which vitamin D deficiency affect the cardiovascular system.

The investigators want to examine the relationship between serum vitamin D levels and the coagulation status in the subjects. The applied the calibrated automated thrombogram (CAT) to assess thrombin generation in plasma as a measure of overall thrombotic activity, and thus to suggest a mechanism that may explain the link between vitamin D deficiency and cardiovascular disease.

Our study population are going to include 100 patients from the internal departments in Emek hospital, who present with chest pain but without acute coronary syndrome (ACS). The investigators will take blood samples from the subjects to measure the serum vitamin D levels and the generation of thrombin. The patients will be divided into four groups according to the level of vitamin D to evaluate the effect of vitamin D levels in the blood on coagulability and thrombotic activity in these patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2013-02
• Study First Submitted: 2013-02-06
• Study First Submitted QC: 2013-02-26
• Study First Posted: 2013-02-27
• Study Start: 2013-04
• Primary Completion: 2014-04
• Study Completion: 2014-04
• Last Update Submitted: 2014-05-04
• Last Update Posted: 2014-05-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

•hospitalized patient with diagnosed of chest pain

Exclusion Criteria

•recent Myocardial ischemia - (in the last 30 days)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
thrombin generation levels and endogenous thrombin potentials	4 month	measuring the thrombin generation and endogenous thrombin potential by the calibrated automated thrombogram (CAT)

Trial Locations

Locations (1)

Haemek medical center; 🇮🇱 Afula, Israel