Nutrition, Arsenic and Cognitive Function in Children
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Arsenic Exposure
- Sponsor
- Columbia University
- Enrollment
- 239
- Locations
- 1
- Primary Endpoint
- Change in in blood arsenic
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
The main goals of this study are to evaluate whether supplementation with folate and vitamin B12 to 8 to 10 year old children, in conjunction with reduction in arsenic exposure, can increase arsenic methylation and lower blood arsenic and blood monomethyl arsenic (as previously observed in adults). The investigators will also explore whether folate and B12 can mitigate arsenic-related decrements in cognitive abilities.
Detailed Description
While reducing arsenic (As) exposure in Bangladesh and the U.S. must continue to be a top priority, this has proven difficult. After decades of efforts to reduce exposure, 42 million people in Bangladesh remain exposed to As above 10 µg/L, the WHO guideline for As in drinking water. Risk for arsenic-related health outcomes lingers for decades after exposure has been reduced. Innovative strategies to lower arsenic exposure and and reduce its potential adverse health effects of As are needed.
Investigators
Mary Gamble
Associate Professor of Environmental Health Sciences
Columbia University
Eligibility Criteria
Inclusion Criteria
- •Age-eligible children of parents enrolled in the Health Effects of Arsenic Longitudinal Study cohort
Exclusion Criteria
- •children who are not attending school
- •children with known physical disability or known chronic illness
Outcomes
Primary Outcomes
Change in in blood arsenic
Time Frame: Up to 12 Weeks
Change in arsenic level in blood is to be measured in mg/L. This is an indicator of the body burden of arsenic and arsenic excretion
Change in arsenic methylation
Time Frame: Up to 12 Weeks
Change in arsenic methylation patterns in blood and urine. The ability to methylate arsenic influences an individual's ability to excrete it in urine.
Change in blood monomethyl arsenic
Time Frame: Up to 12 Weeks
Change in monomethyl arsenic level in blood is to be measured in units of ug/L. This is an indicator of the body burden of arsenic and arsenic methylation capacity.