Observation of Young Patients Who Are Undergoing Surgery for Craniopharyngioma
- Conditions
- Brain and Central Nervous System TumorsWeight ChangesLong-term Effects Secondary to Cancer Therapy in ChildrenPsychosocial Effects of Cancer and Its TreatmentPerioperative/Postoperative Complications
- Registration Number
- NCT00258453
- Lead Sponsor
- German Society for Pediatric Oncology and Hematology GPOH gGmbH
- Brief Summary
RATIONALE: Collecting information on how craniopharyngioma is diagnosed and treated may help doctors predict a patient's response to treatment and help plan the best treatment. It may also help identify the intermediate- and long-term effects of treatment.
PURPOSE: This clinical trial is collecting information on diagnosis, treatment, and quality of life of young patients who are undergoing surgery for craniopharyngioma.
- Detailed Description
OBJECTIVES:
Primary
* Identify all applied therapy strategies in pediatric patients with craniopharyngioma.
* Correlate relapse status with different therapy strategies/modality in these patients.
* Determine the health status (i.e., ophthalmologic, neuropediatric, and endocrine findings) and the health-related quality of life of these patients after treatment.
Secondary
* Determine the incidence of craniopharyngioma in pediatric patients.
* Identify quality control measures for diagnosis and therapy in these patients.
* Improve long-term care through a standardized follow-up program in these patients.
* Determine the efficacy of endocrine substitution for postoperative hypopituitarism in these patients.
* Identify risk factors for developing obesity and correlate the neurotransmitter concentration of leptin and neuropeptide Y in cerebral spinal fluid, serum, and craniopharyngioma cystic fluid with the likelihood of developing obesity in these patients.
* Determine the incidence and extent of eating disorders in these patients.
OUTLINE: This is a multicenter study.
Patients undergo neurologic, endocrine, and ophthalmologic tests and anthropometric diagnostic measurements. Patients then undergo 1 of the following surgical procedures: total resection; incomplete, subtotal, or partial resection; biopsy; or cyst pressure release. Patients whose tumor relapses may undergo a second resection and/or radiotherapy.
Quality of life is assessed at baseline and then periodically thereafter.
After surgery, patients are followed periodically.
PROJECTED ACCRUAL: A total of 120 patients will be accrued for this study.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 120
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (106)
Klinikum Minden
🇩🇪Minden, Germany
A. oe. Landeskrankenhaus Abt. fuer Kinderkrankheiten
🇦🇹Steyr, Austria
Krankenhaus Dornbirn
🇦🇹Dornbirn, Austria
Landes-Kinderkrankenhaus
🇦🇹Linz, Austria
Landeskrankenhaus Feldkirch
🇦🇹Feldkirch-Tisis, Austria
Staedtisches Krankenhaus Dresden - Neustadt
🇩🇪Dresden, Germany
St. Johanns-Spital
🇦🇹Salzburg, Austria
Kliniken der Stadt Koeln gGmbH - Kinderkrankenhaus Riehl
🇩🇪Cologne, Germany
Helios Klinikum Berlin
🇩🇪Berlin, Germany
Universitatsklinikum Carl Gustav Carus
🇩🇪Dresden, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Universitaetsklinikum des Saarlandes
🇩🇪Homburg, Germany
Charite University Hospital - Campus Virchow Klinikum
🇩🇪Berlin, Germany
Carl - Thiem - Klinkum Cottbus
🇩🇪Cottbus, Germany
Universitaets - Kinderklinik
🇩🇪Marburg, Germany
Kinderklinik
🇩🇪Giessen, Germany
Klinikum Bremen-Mitte
🇩🇪Bremen, Germany
Klinikum am Bamberg
🇩🇪Bamberg, Germany
Allgemeinen Krankenhaus Celle Kinderklinik
🇩🇪Celle, Germany
Klinikum Chemnitz gGmbH
🇩🇪Chemnitz, Germany
Vestische Kinderklinik Universitaetsklinik Witten/Herdecke
🇩🇪Datteln, Germany
Universitaetskinderklinik - Universitaetsklinikum Freiburg
🇩🇪Freiburg, Germany
Gemeinschaftskrankenhaus
🇩🇪Herdecke, Germany
Charite - Campus Charite Mitte
🇩🇪Berlin, Germany
Evangelisches Krankenhauus Bielfeld
🇩🇪Biefeld, Germany
Universitaets-Kinderklinik Heidelberg
🇩🇪Heidelberg, Germany
Klinikum Lippe - Detmold
🇩🇪Detmold, Germany
Klinikum Erfurt
🇩🇪Erfurt, Germany
Universitaetsklinikum Goettingen
🇩🇪Goettingen, Germany
Klinikum Duisburg
🇩🇪Duisburg, Germany
Staedtisches Krankenhaus Muenchen - Harlaching
🇩🇪Munich, Germany
Klinik St. Hedwig-Kinderklinik
🇩🇪Regensburg, Germany
Kinderklink Siegen Deutsches Rotes Kreuz
🇩🇪Siegen, Germany
Cnopf'sche Kinderklinik
🇩🇪Nuremberg, Germany
Klinikum Nuernberg - Klinikum Sued
🇩🇪Nuremberg, Germany
Johannes Gutenberg University
🇩🇪Mainz, Germany
Staedtisches Klinik - Kinderklinik
🇩🇪Mannheim, Germany
Krankenhaus Muenchen Schwabing
🇩🇪Munich, Germany
Dr. von Haunersches Kinderspital der Universitaet Muenchen
🇩🇪Munich, Germany
Krankenhaus Neuwerk Klinik fuer Kinder und Jugendmedizin
🇩🇪Moenchengladbach, Germany
LKH Leoben
🇦🇹Leoben, Austria
A. oe. Krankenhaus der Barmherzigen Schwestern Kinderabteilung
🇦🇹Linz, Austria
Allg. Krankenhaus der Stadt Wien Universitaets-Kinderklinik
🇦🇹Wien, Austria
Kinderklinik - Universitaetsklinikum Aachen
🇩🇪Aachen, Germany
Klinikum Augsburg
🇩🇪Augsburg, Germany
Caritas-Krankenhaus Bad Mergentheim
🇩🇪Bad Mergentheim, Germany
Klinikum Bayreuth
🇩🇪Bayreuth, Germany
Kinderklinik der Universitaet Bonn
🇩🇪Bonn, Germany
Klinikum Coburg
🇩🇪Coburg, Germany
Children's Hospital
🇩🇪Cologne, Germany
Klinikum der J.W. Goethe Universitaet
🇩🇪Frankfurt, Germany
Universitats - Kinderklinik
🇩🇪Greiswald, Germany
Kreiskrankenhaus Gummersbach GMBH
🇩🇪Gummersbach, Germany
Universitaetsklinikum Halle
🇩🇪Halle, Germany
University Medical Center Hamburg - Eppendorf
🇩🇪Hamburg, Germany
Kreskrankenhaus Kinderabteilung
🇩🇪Heide, Germany
SLK - Kliniken Heilbronn GmbH - Klinikum am Gesundbrunnen
🇩🇪Heilbronn, Germany
Staedtisches Krankenhaus Hildesheim
🇩🇪Hildesheim, Germany
Clinic for Bone Marrow Transplantation and Hematology and Oncology
🇩🇪Idar-Oberstein, Germany
Klinik und Poliklinik fuer Kinder und Jugendmedizin - Universitaetsklinikum Muenster
🇩🇪Muenster, Germany
Municipal Hospital Complex of the University
🇩🇪Kaiserslautern, Germany
Staedtisches Klinikum Karlsruhe gGmbH
🇩🇪Karlsruhe, Germany
Staedtisches Krankenhaus Kiel
🇩🇪Kiel, Germany
Klinikum Kassel
🇩🇪Kassel, Germany
University Hospital Schleswig-Holstein - Kiel Campus
🇩🇪Kiel, Germany
Klinikum Kemperhof Koblenz
🇩🇪Koblenz, Germany
Klinikum Krefeld GmbH
🇩🇪Krefeld, Germany
Klinik Konstanz
🇩🇪Konstanz, Germany
Kinderkrankenhaus St. Marien
🇩🇪Landshut, Germany
Universitatsklinikum der MA
🇩🇪Magdeburg, Germany
Klinikum Neubrandenburg
🇩🇪Neubrandenburg, Germany
Marienhaus Klinikum St. Elisabeth Neuwied
🇩🇪Neuwied, Germany
Klinikum Oldenburg
🇩🇪Oldenburg, Germany
Marien Hospital
🇩🇪Osnabruck, Germany
Paracelsus - Klinik Osnabrueck
🇩🇪Osnabrueck, Germany
Kinderklinik - Universitaetsklinikum Rostock
🇩🇪Rostock, Germany
Saarbrucker Winterbergkliniken
🇩🇪Saarbrucken, Germany
Klinikum Schwerin
🇩🇪Schwerin, Germany
Johanniter-Kinderklinik
🇩🇪St. Augustin, Germany
Olgahospital
🇩🇪Stuttgart, Germany
Krankenanstalt Mutterhaus der Borromaerinnen
🇩🇪Trier, Germany
Universitaetsklinikum Tuebingen
🇩🇪Tuebingen, Germany
Comprehensive Cancer Center Ulm at Universitaetsklinikum Ulm
🇩🇪Ulm, Germany
St. Marienhospital - Vechta
🇩🇪Vechta, Germany
Staedtisches Klinikum - Howedestrase
🇩🇪Vechta, Germany
Dr. Horst-Schmidt-Kliniken
🇩🇪Wiesbaden, Germany
Universitaets - Kinderklinik Wuerzburg
🇩🇪Wuerzburg, Germany
Helios Kliniken Wuppertal University Hospital
🇩🇪Wuppertal, Germany
Lanssjukhuset Ryhov
🇸🇪Jonkoping, Sweden
Kantonspital Aarau
🇨🇭Aarau, Switzerland
Ospedale "la Carita", Locarno
🇨🇭Locarno, Switzerland
Universitaets-Kinderspital beider Basel
🇨🇭Basel, Switzerland
Kinderspital Luzern
🇨🇭Lucerne 16, Switzerland
Ostschweizer Kinderspital
🇨🇭St. Gallen, Switzerland
Kantonsspital Winterthur
🇨🇭Winterthur, Switzerland
University Children's Hospital
🇨🇭Zurich, Switzerland
St. Annastift Krankenhaus
🇩🇪Ludwigshafen, Germany
Universitaets - Kinderklinik - Luebeck
🇩🇪Luebeck, Germany
Lukaskrankenhaus Neuss
🇩🇪Neuss, Germany
Reinhard-Nieter-Krankenhaus
🇩🇪Wilhelmshaven, Germany
Klinikum der Stadt Wolfsburg
🇩🇪Wolfsburg, Germany
Innsbruck Universitaetsklinik
🇦🇹Innsbruck, Austria
Landeskrankenhaus Klagenfurt
🇦🇹Klagenfurt, Austria
Universitaet Kinderklinik
🇦🇹Graz, Austria
Kardinal Schwarzenbersches Krankenhaus Betriebsgesellschraft mbH Kinderspital
🇦🇹Schwarzach, Austria
St. Anna Children's Hospital
🇦🇹Vienna, Austria