Effect of Endometrial Scratching on Assisted Reproduction Outcomes: a Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 107
- 试验地点
- 2
- 主要终点
- Live birth
研究概览
简要总结
To examine whether endometrial scratching (or injury) using a Pipelle endometrial sampler, performed on the first seven days of the menstrual cycle, is able to improve pregnancy rates in women who will be submitted to a fresh embryo transfer.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •First four days of the menstrual cycle, just before starting controlled ovarian stimulation for planned IVF and fresh embryo transfer.
- •Not have performed endometrial scratching in the last 90 days.
排除标准
- 未提供
研究组 & 干预措施
Endoscratching, non-RIF
Endometrial scratching. Women with no more than 1 previous unsuccessful embryo transfer. Pipelle in the first seven days of the menstrual cycle, just before starting controlled ovarian stimulation.
干预措施: Endometrial Scratching (Procedure)
Control, non-RIF
No intervention. Women with no more than 1 previous unsuccessful embryo transfer.
Endoscratching, RIF
Endometrial scratching. Women with 2 or more previous unsuccessful embryo transfers. Pipelle in the first seven days of the menstrual cycle, just before starting controlled ovarian stimulation.
干预措施: Endometrial Scratching (Procedure)
Control, RIF
No intervention. Women with 2 or more previous unsuccessful embryo transfers.
结局指标
主要结局
Live birth
时间窗: 1 year
The number of participants who delivered a living baby in each arm. The denominator will be the number of women randomized to each arm. This outcome will be assessed by examining the medical records and telephone contact.
次要结局
- Multiple pregnancy(8 weeks)
- Clinical pregnancy(8 weeks)
- Miscarriage(20 weeks)
研究者
Wellington P Martins, MD
Researcher
University of Sao Paulo