New Serological Markers for Eosinophilic Esophagitis

• Conditions: Eosinophilic Esophagitis
• Interventions: Drug: Fluticasone

• Registration Number: NCT01624129
• Lead Sponsor: Technical University of Munich

Brief Summary

The purpose of the study is to investigate if serological parameters such as "extracellular Serum-Tryptase (ST)" and "eosinophilic cationic protein (ECP)" are useful for the diagnosis and surveillance of the eosinophilic esophagitis (EE).

Detailed Description

The eosinophilic esophagitis (EE) is chronic inflammatory and immunological disease. The diagnosis of EE is based upon large numbers of eosinophils in the esophagus on histopathologic examination (\> 20 eosinophils per high powered field in at least one specimen) despite acid suppression with a Proton-Pump-Inhibitor (PPI) for at least two weeks.

There are no diagnostic serological markers for EE so far, so that the purpose of the study is to investigate serological markers which are established in other allergic diseases.

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2011-02-08
• Study First Submitted QC: 2012-06-16
• Study First Posted: 2012-06-20
• Primary Completion: 2012-10
• Status Verified: 2013-01
• Last Update Submitted: 2025-01-08
• Last Update Posted: 2025-01-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• histopathological defined eosinophilic esophagitis
• Age: 18-80

Exclusion Criteria

• missing consent form
• contraindications for performing esophagogastroscopy/taking biopsies of the esophagus

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
eosinophilic esophagitis	Fluticasone	patients with histopathological defined eosinophilic esophagitis

Trial Locations

Locations (1)

II. Medical Department, Technical University Munich; 🇩🇪 Munich, Bavaria, Germany