Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Coronary Artery Disease (HERCET-Study)

Not Applicable

Brief Summary: Patients with coronary artery disease are characterized by an increased cardiovascular risk and they often have low blood high density lipoprotein (HDL)-cholesterol levels or HDL-cholesterol with modified vasculoprotective properties.

The purpose of the present study is to characterize the quality of HDL-cholesterol in patients with coronary artery disease and normal blood HDL-cholesterol levels and to examine the effect of exercise training on the vasculoprotective effects of HDL-cholesterol in these patients. Additionally, the researchers aim to investigate the endothelial function, oxidative stress and the regenerative capacity of the endothelial progenitor cells in patients with coronary artery disease and the changes dependent on physical activity of patients.

Recruitment & Eligibility

Inclusion Criteria

Coronary artery disease
Normal HDL-cholesterol levels in blood:
- > 40 mg/dl (1.03 mmol/L) in males
- > 50 mg/dl (1.29 mmol/L) in females

Exclusion Criteria

Primary Outcome Measures

Name	Time	Method
vasculoprotective and regenerative functions of HDL-cholesterol before and after 8-weeks of exercise training

Secondary Outcome Measures

Name	Time	Method
flow-mediated, endothelium-dependent vasodilation of radial artery measured by ultrasound

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