The cross-sectional study of physical, biochemical and clinical parameters, genetics, and epigenetics of frailty in Thai community-dwelling older people

Completed

• Conditions: Frailty status transition in the frail and pre-frail older people; Frail, prefrail, pre-frail, robust, frailty status, older, elder, nutrition, kihon, kihon checklist, frail scale, MNA, GPAQ, calf circumference, TGDS-15, depression, cognitive impairment, genetics, epigenetics, DNA methylation, B vitamins

• Registration Number: TCTR20240626002
• Lead Sponsor: ational Research Council of Thailand (NRCT)

Brief Summary

This study highlights the significant prevalence of frailty and pre-frailty among the Thai elderly. The identification of DNA methylation markers associated with frailty has the potential to revolutionise early detection strategies. This novel approach has the potential to significantly improve healthcare delivery for the ageing population in Thailand and beyond.

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-11-29
• Study Start: 2024-06-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 848

Inclusion Criteria

1. Thai elderly patients age 60 years or older.

Exclusion Criteria

1.Patients who cannot communicate 2.Cognitive impairment ( TMSE <18) 3.Life expectancy <6 months 4.Unstable condition ( Congestive heart failure, Cardiovascular or respiratory failure , Blood pressure <90/60mmHg, or >180/100mmHg, heart rate >100bpm, oxygen saturation < 92%, Respiratory rate 22/min) 5.disabled people 6. people with prosthesis which disturbs body composition measurement by bioelectrical impedance analysis 7.History of hospitalization within 3 months

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Physical characteristics Cross-sectional at the recruiment chair stand, functional reach, gait speed in 4 meters, hand grip strength, and sit and reach,Blood parameters Cross-sectional at the recruiment chemiluminescence, electrical resistance, hydrodynamic focusing, SLS-haemoglobin, and high-performance liquid chromatography methods and Chronic Kidney Disease Epidemiology Collaboration equation

Secondary Outcome Measures

Name	Time	Method
Genetics and epigenetics profiles Cross-sectional at the recruiment sanger sequencing, and colorimetric method and Infinium MethylationEPIC array