PRF for Treating Maxillary Gingival Recession

Not Applicable

Completed

• Conditions: Gingival Recession
• Interventions: Procedure: Gingival coverage using coronally advanced flap and a connective tissue graft; Procedure: Gingival coverage using coronally advanced flap and platelet rich fibrin membranes

• Registration Number: NCT05267015
• Lead Sponsor: Arab American University (Palestine)

Brief Summary

This is a split-mouth, randomized, controlled clinical trial that aims to evaluate the clinical efficacy of platelet-rich fibrin (PRF) membranes in conjunction with coronally advanced flap (CAF) in treating maxillary gingival recession defects.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-03
• Primary Completion: 2021-08-15
• Study Completion: 2021-11-14
• Status Verified: 2022-02
• Study First Submitted: 2022-02-14
• Study First Submitted QC: 2022-02-23
• Last Update Submitted: 2022-02-23
• Study First Posted: 2022-03-04
• Last Update Posted: 2022-03-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Greater than 18 years old
• Bilateral Miller class I + II recession in the upper jaw

Exclusion Criteria

• Smokers
• Patients with systemic diseases that could interfere with the healing
• Patients undergoing bisphosphonate therap .Patients who previously received radiation therapy of the jaws.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
coronally advanced flap with connective tissue graft	Gingival coverage using coronally advanced flap and a connective tissue graft	After randomization a subepithelial connective tissue graft along with coronally advanced flap is applied to one maxillary quadrant to cover the recession.
coronally advanced flap with platelet rich fibrin membranes	Gingival coverage using coronally advanced flap and platelet rich fibrin membranes	After randomization platelet rich fibrin membranes along with coronally advanced flap are applied to the other maxillary quadrant to cover the recession.

Primary Outcome Measures

Name	Time	Method
Increase in gingival height (recession coverage)	six weeks	The measurements of the increase in gingival height (recession coverage) using a linear evaluation (corono-apical direction) with a periodontal probe (Merrit-B; Hu-Friedy, Chicago, IL, USA) at the interventions sites to the nearest 0.5 mm. Registration of the recession height was done before treatment and after 6 weeks.
Shrinkage in gingival height	six months	To assess the shrinkage of the gingival height, the amount of gingival height vestibular to the treated teeth in a corono-apical direction was measured after the surgery and after six months.

Secondary Outcome Measures

Name	Time	Method
Postoperative pain visual analog scores (VAS) and surgery time	two weeks	This questionnaire used 100 mm visual analog scores VAS to evaluate the amount of pain, ranging from 0 (no pain) to 10 (worst pain imaginable), and the amount of swelling. Patients were asked to fill in the VAS scales at day 7 and day 14 at suture removal. The time of surgery was measured of both treatment options. Timing started at the moment of first incision until the last suture.

Trial Locations

Locations (1)

Arab American University; 🇵🇸 Ramallah, Palestinian Territory, occupied