A Randomized Comparison of Intravitreal ISIS 2922 Plus Ganciclovir Versus Ganciclovir as Treatment for Patients With Cytomegalovirus Retinitis ( CMVR )
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 194
- 试验地点
- 18
研究概览
简要总结
To determine the clinically safe and effective dose of intravitreal ISIS 2922 alone and as an additive antiviral therapy to ganciclovir in AIDS patients with cytomegalovirus (CMV) retinitis.
详细描述
In Stage 1 of the study, 20 patients receive one of two doses of ISIS 2922 on days 1, 8, and 15 (Induction) then every 14 days (maintenance), with ganciclovir given daily during both Induction and Maintenance. Escalation to the second dose does not occur until all patients at the first dose level have reached their first maintenance dose (day 29). In Stage 2 of the study, 174 patients are randomized to receive either a) ISIS 2922 at the dose established in Stage 1 on days 1, 8, and 15 and then every 14 days, with ganciclovir given daily during both Induction and Maintenance, or b) ganciclovir daily for 14 consecutive days and then a lower dose as maintenance. Patients may continue to receive ISIS 2922 biweekly if the dose is safe and their CMV retinitis is clinically controlled. Per 2/8/96 amendment, patients are now in Stage 2 at 150 mcg.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients must have:
- •CMV retinitis that is not adequately controlled (previously diagnosed patients with smoldering CMV retinitis or those with active CMV retinitis borders on indirect ophthalmoscopy).
- •No more than one previous progression of CMV retinitis.
排除标准
- •Co-existing Condition:
- •Patients with the following symptoms or conditions in the eye to be treated are excluded:
- •External ocular infection.
- •Other herpetic infections of the retina, toxoplasma retinochoroiditis, or other disease of the fundus.
- •Ocular condition that will obstruct visualization of the posterior ocular structures.
- •Retinal detachment.
- •Silicone oil in eye.
- •Patients with the following other symptoms or conditions are excluded:
- •Known or suspected allergy to phosphorothioate oligonucleotides.
- •Syphilis.
- •Retinal pigment epithelial stippling not associated with CMV retinitis.
- •Pseudoretinitis pigmentosa.
- •Chronic diarrhea that would impair absorption of oral ganciclovir.
- •Intolerance to ganciclovir.
- •Concurrent Medication:
- •Foscarnet or other anti-CMV agents other than ganciclovir.
- •Mellaril.
- •Stelazine.
- •Thorazine.
- •Clofazimine.
- •Ethambutol/fluconazole combination.
- •Investigational medications for CMV retinitis.
- •Concurrent Treatment:
- •Investigational procedures for CMV retinitis.
- •Patients with the following prior conditions are excluded:
- •History of surgery to correct retinal detachment in eye to be treated.
- •History of intolerance to ISIS
- •Prior Medication:
- •Prior ganciclovir implant for CMV retinitis.
- •More than 4 months of prior ganciclovir.