ACTRN12615000910505
Recruiting
Phase 4
In patients presenting to the Emergency Department with acute migraine, is propofol more effective than placebo for headache resolution by one hour.
Dandenong Hospital0 sites60 target enrollmentSeptember 1, 2015
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Neurological - Other neurological disorders
- Sponsor
- Dandenong Hospital
- Enrollment
- 60
- Status
- Recruiting
- Last Updated
- 6 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Acute migraine, 18 to 65 years of age, patient reported pain on arrival of severity of 4 or more on the 1 to 10 numerical rating scale.
Exclusion Criteria
- •Any doubt about diagnosis of migraine for any reason, any associated head injury, any known intracranial pathology, systolic blood pressure less than100 mmHg, use of defined drugs in previous 4 hours (opioids, ergotamine, triptans, neuroleptics or antemetics other than ondansetron), known allergy to propofol, intralipid, egg or soy products. Migraine WITH aura comprising of neurological symptoms, aura being defined as: at least 2 of these, fully reversible aura symptoms: visual symptoms (flickering lights/spots/lines/visual loss) or Sensory symptoms (pins/needles/numbness), or Dysphasic speech disturbance; And at least 2 of these: Homonymous visual and/or unilateral sensory symptoms or at least one aura symptom developing over \> 5 min, or Aura symptom(s) lasting between 5 and 60 minutes
Outcomes
Primary Outcomes
Not specified
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