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Clinical Trials/DRKS00015085
DRKS00015085
Completed
Not Applicable

FallriskPD: fall risk evaluation in Parkinson’s disease using intelligent gait analysis. - FallRiskPD

niversitätsklinikum Erlangen, Molekular-Neurologische Abteilung0 sites51 target enrollmentSeptember 3, 2018
ConditionsG20.1

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
G20.1
Sponsor
niversitätsklinikum Erlangen, Molekular-Neurologische Abteilung
Enrollment
51
Status
Completed
Last Updated
last year

Overview

Brief Summary

This study present a data set containing real-world gait and unsupervised 4x10-Meter-Walking-Tests of 40 PD patients, continuously recorded with foot-worn inertial sensors over a period of two weeks. In this prospective study, falls were self-reported during a three-month follow-up phase, serving as ground truth for fall risk prediction. The purpose of this study was to compare different data aggregation approaches and machine learning models for the prospective prediction of fall risk using gait parameters derived either from continuous real-world recordings or from unsupervised gait tests. The highest balanced accuracy of 74.0% (sensitivity: 60.0%, specificity: 88.0%) was achieved with a Random Forest Classifier applied to the real-world gait data when aggregating all walking bouts and days of each participant. Our findings suggest that fall risk can be predicted best by merging the entire two-week realworld gait data of a patient, outperforming the prediction using unsupervised gait tests (68.0% balanced accuracy) and contribute to an improved understanding of fall risk prediction.

Registry
who.int
Start Date
September 3, 2018
End Date
June 22, 2021
Last Updated
last year
Study Type
Observational
Sex
All

Investigators

Sponsor
niversitätsklinikum Erlangen, Molekular-Neurologische Abteilung

Eligibility Criteria

Inclusion Criteria

  • Diagnosis of a Parkinson syndrome in accordance with the guideline of the German Society of Neurology (Hoehn \& Yahr stadium I\-III)
  • \- Ability to walk for 2 Minutes without assistance
  • \- Ability to speak and read
  • \- Ability to use an application running on a smart device
  • \- informed consent with understanding of the study procedures

Exclusion Criteria

  • \- Aphasia and Alexia
  • \- Impaired vision which makes reading unfeasible
  • \- Regular use of gait aids
  • \- Decompensated cardiopulmonary restrictions
  • \- Maximal walking distance \< 100 meter
  • \- Inability to understand the informed consent and the study procedures
  • \- Distinct musculoskeletal disorder, which highly restricts movement and gait abilities

Outcomes

Primary Outcomes

Not specified

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