Relationship Between Obesity and Severe Acute Respiratory Syndrome Coronavirus-2 in Patient With SARS-CoV-2 Admitted in Intensive Care : A Multicenter Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1,200
- 试验地点
- 1
- 主要终点
- Relationship between body mass index (BMI) and SARS-CoV-2
研究概览
简要总结
This study will involve collection of pseudonymized data from hospital-based data reporting at multiple international sites. Collating data from a large volume of patients with COVID-19 admitted in ICU across multiple international sites will enable investigation of whether obesity is a risk factor for complicated from of SARS-CoV-2 in adult patients and whether this association is independent of other cardiometabolic risk factors.
详细描述
The COVID-19 pandemic is characterized by a high frequency of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), who often require invasive mechanical ventilation (IMV). Body mass index (BMI) was however rarely mentioned in early clinical reports.
Disease severity gradually increased with body mass index (BMI) categories among patients admitted in intensive care unit (ICU) for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the need for invasive mechanical ventilation (IMV), reaching 85% in patients with class II or III obesity ( BMI > 35 kg/m2).
In summary, there is an urgent need for more evidence on the specific role played by obesity in the development of COVID-19 complications, and more particularly of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participant is aged 18 years or over
- •Has been admitted to ICU with COVID-19 disease.
- •COVID-19 disease has been confirmed by PCR for SARS-CoV-2
- •Height and weight or BMI on admission has been recorded
- •Data has been collected in an ethical manner as part of a national database or clinical auditing process approved by the local institution or collaboration
排除标准
- •There are no exclusion criteria
结局指标
主要结局
Relationship between body mass index (BMI) and SARS-CoV-2
时间窗: 3 months
The primary objective of this study is to investigate the relationship between obesity, as determined by body mass index (BMI), and severe pneumonia, as defined by the need of invasive mechanical ventilation ( IMV), among patient admitted in ICU for SARS-CoV-2, across multiple centers, in multiple countries.
次要结局
- Associations between BMI and outcomes is independent of the known cardiometabolic risk factors(3 months)
- Investigate the modifying effects of age and sex on the associations between BMI and outcome: Invasive mechanical ventilation(3 months)
- Investigate the modifying effects of age and sex on the associations between BMI and outcome: mortality(3 months)