NCT00500305已完成不适用
The Use of B-type Natriuretic Peptide (BNP) to Predict Closure of a Patent Ductus Arteriosus (PDA) in Premature Infants
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 主要终点
- Number of indomethacin doses given on study
研究概览
简要总结
A patent ductus arteriosus (PDA) is associated with increased morbidity in premature infants. Standard indomethacin treatment is associated with intestinal and renal morbidity. B-type natriuretic peptide is elevated in significant PDAs. This study will determine whether BNP guided therapy could reduce doses of indomethacin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- — 至 4 Months（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Infants with echocardiographically confirmed PDA
- •Infants determined by attending physician to require PDA closure
排除标准
- •infants with congenital hearts disease
- •infants with creatinine value > 2.0
结局指标
主要结局
Number of indomethacin doses given on study
时间窗: 2 days
次要结局
- Rate of Chronic lung disease(36 weeks corrected gestational age)
- rate of PDA ligation(Discharge from NICU)
研究者
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