Effect of ventilation during complete anaesthesia on release of chemicals of lung infection /injury in patients survived from COVID-19
- Conditions
- Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhereHealth Condition 2: O- Medical and Surgical
- Registration Number
- CTRI/2022/07/043797
- Lead Sponsor
- Department of Anaesthesiology Pain Medicine and Critical Care AIIMS New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1.Patients more or equal to 18 years classified as American Society of Anaesthesiologists (ASA) physical status I/II/ III scheduled for elective or emergency extra thoracic surgery under general anaesthesia
2.Minimum 4 week interval between COVID-19 infection and the scheduled surgery
3.Pulmonary involvement during COVID -19 infection as evident by dyspnea or hypoxemia, chest Xray/CECT findings or oxygen requirement
1.Post COVID-19 without pulmonary symptoms/radiological involvement/oxygen requirement/undiagnosed COVID.
2.Patients with history or clinical signs of lung disease before COVID-19 infection
3.Patients on ongoing immunosuppression by drugs for underlying condition
4.Elevated leukocyte count or clinical signs of a systemic infection
5.Intra-thoracic surgery
6.ASA class IV
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To monitor proinflammatory cytokine responses as an estimate of lung inflammation/injury during mechanical ventilation in COVID-19 survivors who had pulmonary involvementTimepoint: baseline, at the end of surgery, 1 hour after the surgery
- Secondary Outcome Measures
Name Time Method .To determine incidence of post-operative pulmonary complications (POPC) in patients of general anesthesia with mechanical ventilation <br/ ><br>.To determine whether serum and bronchoalveolar lavage fluid (BALF) biomarkers are capable of identifying patients at risk of POPC <br/ ><br>.To determine the correlation between CT score of pulmonary involvement with the serum and BALF biomarkers of lung injury <br/ ><br>.To assess difference in length of hospital stay of the patients in both groups <br/ ><br>Timepoint: 7 days and 6 months