NCT02452554已完成2 期
A Phase 2 Study of IMGN901 (Lorvotuzumab Mertansine; NSC#: 783609) in Children With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor (MPNST) and Synovial Sarcoma
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 62
- 试验地点
- 136
- 主要终点
- Objective Response by Response Evaluation Criteria in Solid Tumors Version 1.1
研究概览
简要总结
This phase II trial studies how well lorvotuzumab mertansine works in treating younger patients with Wilms tumor, rhabdomyosarcoma, neuroblastoma, pleuropulmonary blastoma, malignant peripheral nerve sheath tumor (MPNST), or synovial sarcoma that has returned or that does not respond to treatment. Antibody-drug conjugates, such as lorvotuzumab mertansine, are created by attaching an antibody (protein used by the body?s immune system to fight foreign or diseased cells) to an anti-cancer drug. The antibody is used to recognize tumor cells so the anti-cancer drug can kill them.
详细描述
PRIMARY OBJECTIVES:
I. To assess the efficacy of IMGN901 (lorvotuzumab mertansine) in Wilms tumor, rhabdomyosarcoma, neuroblastoma and other cluster of differentiation (CD)56-expressing tumors such as pleuropulmonary blastoma, malignant peripheral nerve sheath tumor (MPNST) and synovial sarcoma.
II. To determine the tolerability of the adult recommended phase 2 dose (RP2D) of IMGN901 administered as an intravenous infusion, administered on days 1 and 8 of a 21-day cycle, to children with refractory Wilms tumor, rhabdomyosarcoma, neuroblastoma, pleuropulmonary blastoma, MPNST, or synovial sarcoma.
III. To define and describe the toxicities of IMGN901 administered on this schedule.
EXPLORATORY OBJECTIVES:
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 12 Months 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients must have had histologic verification of one of the malignancies listed below at original diagnosis or at relapse
- •Primary strata
- •Wilms tumor
- •Rhabdomyosarcoma
- •Neuroblastoma
- •Secondary strata: miscellaneous CD56-expressing tumors:
- •Pleuropulmonary blastoma
- •Malignant peripheral nerve sheath tumor (MPNST)
- •Synovial sarcoma
- •Patients must have radiographically measurable disease (with the exception of those with neuroblastoma)
- •Measurable disease is defined as the presence of at least one lesion on magnetic resonance imaging (MRI) or computed tomography (CT) scan that can be accurately measured with the longest diameter a minimum of 10 mm in at least one dimension (CT scan slice thickness no greater than 5 mm)
- •Note: the following do not qualify as measurable disease:
- •Malignant fluid collections (e.g., ascites, pleural effusions)
- •Bone marrow infiltration except that detected by metaiodobenzylguanidine (MIBG) scan for neuroblastoma
- •Lesions only detected by nuclear medicine studies (e.g., bone, gallium or positron emission tomography [PET] scans) except as noted in patients with neuroblastoma who do not have measurable disease but have MIBG-avid evaluable disease
- •Elevated tumor markers in plasma or cerebrospinal fluid (CSF)
- •Previously radiated lesions that have not demonstrated clear progression post radiation
- •Leptomeningeal lesions that do not meet the measurements noted above
- •Patients with neuroblastoma who do not have measurable disease but have MIBG-avid evaluable disease are eligible
- •Patients must have a Lansky or Karnofsky performance status score of >= 50, corresponding to Eastern Cooperative Oncology Group (ECOG) categories 0, 1 or 2; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age; patients who are unable to walk because of paralysis, but who are up in a wheelchair, will be considered ambulatory for the purpose of assessing the performance score
- •Patients must have fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study
- •Patients must have received standard treatment appropriate for their tumor type
- •Myelosuppressive chemotherapy: patients with solid tumors must not have received myelosuppressive chemotherapy within 3 weeks of enrollment onto this study (6 weeks if prior nitrosourea)
- •Hematopoietic growth factors: at least 14 days must have elapsed after receiving pegfilgrastim and least 7 days must have elapsed since the completion of therapy with a non-pegylated growth factor
- •Biologic (anti-neoplastic agent): at least 7 days must have elapsed since completion of therapy with a biologic agent; for agents that have known adverse events occurring beyond 7 days after administration, this period prior to enrollment must be extended beyond the time during which adverse events are known to occur
- •Monoclonal antibodies: at least 3 half-lives must have elapsed since prior therapy that included a monoclonal antibody
- •Radiotherapy: >= 2 weeks must have elapsed since local palliative external beam radiation therapy (XRT) (small port); >= 6 weeks must have elapsed since treatment with therapeutic doses of MIBG; >= 3 months must have elapsed if prior craniospinal XRT was received, if >= 50% of the pelvis was irradiated, or if total body irradiation (TBI) was received; >= 6 weeks must have elapsed if other substantial bone marrow irradiation was given
- •Stem cell transplant or rescue without TBI: no evidence of active graft vs. host disease and >= 2 months must have elapsed since transplant
- •For patients with solid tumors without bone marrow involvement: peripheral absolute neutrophil count (ANC) >= 1000/uL
- •For patients with solid tumors without bone marrow involvement: platelet count >= 100,000/uL (transfusion independent, defined as not receiving platelet transfusions within a 7 day period prior to enrollment)
- •For patients with solid tumors and known bone marrow metastatic disease: peripheral absolute neutrophil count (ANC) >= 750/uL
- •For patients with solid tumors and known bone marrow metastatic disease: platelet count >= 75,000/uL (transfusion independent, defined as not receiving platelet transfusions for at least 7 days prior to enrollment)
- •Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 or a serum creatinine based on age/gender as follows:
- •Age 1 to < 2 years: maximum serum creatinine: 0.6 mg/dL in males and females
- •Age 2 to < 6 years: maximum serum creatinine: 0.8 mg/dL in males and females
- •Age 6 to < 10 years: maximum serum creatinine: 1 mg/dL in males and females
- •Age 10 to < 13 years: maximum serum creatinine: 1.2 mg/dL in males and females
- •Age 13 to < 16 years: maximum serum creatinine: 1.5 mg/dL in males and 1.4 mg/dL in females
- •Age >= 16 years: maximum serum creatinine: 1.7 mg/dL in males and 1.4 mg/dL in females
- •Total bilirubin =< 1.5 x upper limit of normal (ULN) for age
- •Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 110 U/L (for the purpose of this study, the ULN for SGPT is 45 U/L)
- •Serum albumin >= 2 g/dL
- •Shortening fraction of >= 27% by echocardiogram, or ejection fraction of >= 50% by gated radionuclide study
- •Patients with seizure disorder may be enrolled if on anticonvulsants and well controlled
- •All patients and/or their parents or legal guardians must sign a written informed consent
- •All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met
排除标准
- •Patients who are pregnant or breast-feeding are not eligible for this study; negative pregnancy tests must be obtained in girls who are post-menarchal; males or females of reproductive potential may not participate unless they have agreed to use an effective contraceptive method for the duration of study therapy and for 4 weeks after the last dose of study therapy; breastfeeding women are excluded
- •Concomitant medications
- •Corticosteroids: patients requiring corticosteroids who have not been on a stable or decreasing dose of corticosteroid for the 7 days prior to enrollment are not eligible
- •Patients who have received previous treatment with IMGN901 are not eligible
- •Investigational drugs: patients who are currently receiving another investigational drug are not eligible
- •Anti-cancer agents: patients who are currently receiving other anti-cancer agents are not eligible
- •Anti-graft-versus-host disease (GVHD) or agents to prevent organ rejection post-transplant: patients who are receiving cyclosporine, tacrolimus or other agents to prevent either graft-versus-host disease post bone marrow transplant or organ rejection post-transplant are not eligible for this trial
- •Patients who have a CNS toxicity > grade 2 are not eligible
- •Patients must not have known active central nervous system (CNS) metastases; patients with known central nervous system metastases are excluded unless treated surgically or with radiotherapy, and stable with no recurrent lesions for at least 6 months
- •Patients who have baseline peripheral neuropathy >= grade 2 are not eligible
- •Patients who have an uncontrolled infection are not eligible
- •Patients who in the opinion of the investigator may not be able to comply with the safety monitoring requirements of the study are not eligible
结局指标
主要结局
Objective Response by Response Evaluation Criteria in Solid Tumors Version 1.1
时间窗: Up to 18 weeks (6 courses)
The best response of disease will be examined separately in each stratum. A responder is defined as a patient who achieves a best response of partial response or complete response on the study. Response rates will be calculated as the percent of evaluable patients who are responders, and Clopper-Pearson confidence intervals will be constructed.
Incidence of Toxicities of Lorvotuzumab Mertansine, Using the NCI Common Terminology Criteria for Adverse Events Version 4.0
时间窗: Up to 12 months (17 courses)
Toxicity tables will be constructed to summarize the observed incidence by type of toxicity and grade for toxicities with Possible, Probable, or Definite attribution to the study drug. Tables will summarize incidence by cycle.
次要结局
未报告次要终点
研究者
研究点 (136)
Loading locations...
相似试验
进行中（未招募）
2 期
Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic LeukemiaRecurrent B Acute Lymphoblastic LeukemiaRecurrent B Lymphoblastic LymphomaRefractory B Acute Lymphoblastic LeukemiaRefractory B Lymphoblastic LymphomaNCT02981628Children's Oncology Group80
招募中
2 期
Mosunetuzumab in Patients With Newly Diagnosed Extranodal Marginal Zone LymphomaExtranodal Marginal Zone LymphomaNCT06569680Izidore Lossos, MD35
已完成
2 期
Sunitinib Malate in Treating Younger Patients With Recurrent, Refractory, or Progressive Malignant Glioma or EpendymomaChildhood Cerebellar Anaplastic AstrocytomaChildhood Cerebral Anaplastic AstrocytomaChildhood Cerebral AstrocytomaChildhood Infratentorial EpendymomaChildhood Mixed GliomaChildhood OligodendrogliomaChildhood Supratentorial EpendymomaRecurrent Childhood Cerebellar AstrocytomaRecurrent Childhood Cerebral AstrocytomaRecurrent Childhood EpendymomaRecurrent Childhood Subependymal Giant Cell AstrocytomaNCT01462695National Cancer Institute (NCI)30
进行中（未招募）
2 期
Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare TumorsAdrenal Cortical CarcinomaChildhood Clear Cell Sarcoma of Soft TissueClear Cell Sarcoma of Soft TissueOsteosarcomaRecurrent Adrenal Cortical CarcinomaRecurrent Alveolar Soft Part SarcomaRecurrent Clear Cell Sarcoma of Soft TissueRecurrent Ewing SarcomaRecurrent HepatoblastomaRecurrent Hepatocellular CarcinomaRecurrent Kidney Wilms TumorRecurrent Malignant Solid NeoplasmRecurrent OsteosarcomaRecurrent Primary Malignant Central Nervous System NeoplasmRecurrent Renal Cell CarcinomaRecurrent RhabdomyosarcomaRecurrent Soft Tissue SarcomaRecurrent Thyroid Gland Medullary CarcinomaRefractory Adrenal Cortical CarcinomaRefractory Alveolar Soft Part SarcomaRefractory Clear Cell Sarcoma of Soft TissueRefractory Ewing SarcomaRefractory HepatoblastomaRefractory Hepatocellular CarcinomaRefractory Malignant Solid NeoplasmRefractory OsteosarcomaRefractory Primary Central Nervous System NeoplasmRefractory Primary Malignant Central Nervous System NeoplasmRefractory Renal Cell CarcinomaRefractory RhabdomyosarcomaRefractory Soft Tissue SarcomaRefractory Thyroid Gland Medullary CarcinomaRefractory Wilms TumorSoft Tissue SarcomaSolid NeoplasmThyroid Gland Medullary CarcinomaWilms TumorAlveolar Soft Part SarcomaCentral Nervous System NeoplasmHepatoblastomaRenal Cell CarcinomaRhabdomyosarcomaEwing SarcomaHepatocellular CarcinomaNCT02867592National Cancer Institute (NCI)109
进行中（未招募）
2 期
Mosunetuzumab and Polatuzumab Vedotin for Untreated Follicular LymphomaLymphoma, FollicularFollicular LymphomaNCT05410418Washington University School of Medicine34