Regulation of the Plasma Triglyceride Extraction in Muscle in Insulin Resistance
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Triglyceride extraction across the forearm
研究概览
简要总结
Increased accumulation of fat into the muscles is associated with what is called insulin-resistant state, which is a pre-diabetic state. The purpose of this research is to find out how fat circulating in the blood following fat consumption is taken up by the muscles in healthy people as well as people that are insulin-resistant. The investigators are specifically interested in how a hormone called insulin is involved in this process. Findings from this research will contribute to our understanding of why insulin-resistant people have increased accumulation of fat in their muscles, and ultimately help to design appropriate interventions to prevent type 2 Diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Body mass index (BMI): < 25 kg/m2 or > 30 kg/m2;
- •Insulin sensitivity index (ISI): insulin-sensitive ISI ≥ 7, insulin-resistant ISI ≤ 5.
排除标准
- •Medication or supplements known to affect either endothelial function or lipid metabolism (i.e. arginine, protein, fish oil)
- •Acute illness
- •Uncontrolled metabolic disease, including liver or renal disease
- •Atrial fibrillation, history of syncope, limiting or unstable angina, congestive heart failure, known or suspected right-to-left, bi-directional or transient right-to-left cardiac shunts
- •Cardiac pacemaker or other medical device implanted in the body
- •Pulmonary hypertension or other unstable cardiopulmonary conditions
- •ECG documented abnormalities or valvular disease
- •Low hemoglobin or hematocrit (i.e., lower than accepted laboratory values)
- •History of hypertension or elevated blood pressure (systolic, >140 mmHg or a diastolic, >95 mmHg)
- •History of hyperlipidemia or plasma triglyceride concentration >200 mg/dl
- •Diagnosed diabetes, or 2-h plasma glucose >200 mg/dl during an oral glucose tolerance test
- •Current participation in a weight-loss regimen, including extreme dietary practices
- •Use of anabolic steroids or corticosteroids (within 3 months)
研究组 & 干预措施
Insulin-Sensitive
One group consists of insulin sensitive volunteers.
干预措施: Insulin (Drug)
Insulin-Sensitive
One group consists of insulin sensitive volunteers.
干预措施: NG-monomethyl-L-arginine (Drug)
Insulin-Resistant
One group consists of insulin resistant volunteers.
干预措施: Insulin (Drug)
结局指标
主要结局
Triglyceride extraction across the forearm
时间窗: Measured during a 7-hour infusion study
次要结局
- Muscle microvascular blood volume(Selected 15-minute periods during the 7 hour infusion study)