Validate the Dosimetric Parameters That Correlate With Acute Hematologic Toxicity (HT) in Patients With Rectal Cancer Treated With Neoadjuvant Chemoradiotherapy
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 90
- 主要终点
- the grade of acute hematologic toxicity
研究概览
简要总结
The purpose of this study is to validate the dosimetric parameters that correlate with acute hematologic toxicity (HT) in patients with rectal cancer treated with neoadjuvant chemoradiotherapy.
详细描述
The investigators' ongoing retrospective study investigated the clinical and dosimetric parameter (dosimetry of pelvic bone marrow) which relate with acute hematologic toxicity in patient with rectal cancer treated with neoadjuvant chemoradiotherapy. In order to validate the dosimetric limitation of pelvic bone marrow in decreasing the intensity of HT, the investigators want to conduct a study to observe the acute HT without assigning any specific interventions to the subjects of the study, who will receive the standard treatment according to the multidisciplinary team's (MDT) decision and patient choice. Therefore, this study's type is observational.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •rectal cancer
- •receive neoadjuvant chemoradiotherapy
排除标准
- •hematological system disorders
结局指标
主要结局
the grade of acute hematologic toxicity
时间窗: 5-6 weeks
Hematologic Adverse Events That Are Related to Pelvic Bone Marrow Irradiation
次要结局
未报告次要终点
