The Effect of Short Term Omega-3 Supplementation on Exercise Performance and Neuromuscular Function.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Change from baseline in maximum voluntary contraction force
研究概览
简要总结
Nerves are the rate limiting factor that control muscle function. However, it is unknown if a nutritional supplement can change the nerve-muscle interaction, and therefore alter human performance. This study will be the first to examine the effects of omega-3 supplementation on neuromuscular function in trained individuals.
详细描述
Participants will come to the lab for 3 sessions, one for familiarization and two for testing.
Familiarization - At this time, anthropometric measurements including height, weight, BMI (body mass index) and body composition will be determined. Participants will be familiarized with the interpolated twitch technique and performing a maximal voluntary contraction of the quadriceps muscle. Next, Participant's 10 repetition maximum squat weight will be established by starting at a participant selected weight and gradually increasing until only 10 squat repetitions can be completed. A VO2max (maximum oxygen consumption) test will be performed on a cycle ergometer using standard methods.
On testing sessions 1 and 2 the following neuromuscular and performance measures will be evaluated:
- Quadriceps muscle voluntary activation will be assessed using the interpolated twitch technique and doublet twitch technique. Participants will be seated and instructed to perform three 5 second maximal voluntary isometric contractions at least 1 minute apart - participant's ankle will be restrained by a padded cuff attached to a load cell.
For the second maximal isometric contraction at 3 seconds into the contraction, a square wave superimposed stimulus will be delivered for 1 milliseconds to the femoral nerve from a monopolar touch-proof cathode electrode secured in the femoral triangle. 2, 7 and 12 seconds after the contraction a resting twitch will be delivered for comparison of muscle force.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •At least 2 years training experience that includes resistance training, specifically back squat
- •Successfully completing a Par-Q questionnaire
排除标准
- •Individuals that have or are currently taking an omega-3 and/or omega-6 supplement within 4 weeks of the study
- •Individuals that have taken mammalian based omega-3 or 6 supplements in the past 6 months
- •Individuals consuming fish more than twice per week within 4 weeks of the study
研究组 & 干预措施
Olive oil
Participants will consume 5 mL of olive oil with 1000 IU vitamin D3 for 21 days.
干预措施: Olive oil (Dietary Supplement)
Omega-3
Participants will consume 5 mL of omega-3 (2333 mg essential fatty acids) with 1000 IU vitamin D3 for 21 days.
干预措施: Omega-3 (Dietary Supplement)
结局指标
主要结局
Change from baseline in maximum voluntary contraction force
时间窗: 21 days
Participants will be seated with their right knee fixed at 90°. The right ankle will be restrained by a padded cuff attached in series to a load cell. Participants will be instructed to contract their quadriceps maximally by trying to extending their leg. The load cell will measure the maximum force produced.
次要结局
- Change from baseline in quadriceps voluntary activation(21 days)
- Change from baseline in number of 10RM squats(21 days)
- Change from baseline in number of push-ups(21 days)
- Change from baseline in Wingate test fatigue index(21 days)
- Change from baseline in Wingate test cadence(21 days)
- Change from baseline in vertical jump height(21 days)
- Change from baseline in 250 kJ cycling time trial average power(Baseline and 21 days)
- Change from baseline in Wingate test peak power(21 days)
- Change from baseline in 250 kJ cycling time trial time to completion(Baseline and 21 days)
- Change from baseline in Pre/Post maximal voluntary contraction force(21 days)
- Change from baseline in Wingate test average power(21 days)
研究者
Thomas Wolever
Professor
University of Toronto