Meloxicam Versus Ibuprofen for Pain Control After Third Molar Exodontia in Adult Patients

Phase 4

Not yet recruiting

• Conditions: Dental Pain; Sensation Disorders
• Interventions: Drug: meloxicam 7,5mg

• Registration Number: NCT06704113
• Lead Sponsor: Universidad Austral de Chile

Brief Summary

Third molar extraction is a common dental procedure, offently related with pain and swelling. The purpose of this study is to evaluate if Meloxicam has a better effect relieving pain after the extraction than Ibuprofen, one of the most common pain relieving drugs administered after this procedure.

Detailed Description

Summary: Third molar extractions are one of the most common procedures in dental practice. However, pain and swelling as postoperative sequelae are inevitable. Depending on the level of pain, which can range from moderate to severe, this symptomatology can be accompanied with pharmacological treatment, thus generating a less traumatic recovery for the patient. It is currently known that non-steroidal anti-inflammatory drugs (NSAIDs) have proven to be effective for the treatment of mild and moderate postoperative pain. Due to the wide variety of NSAIDs, it is important to know how to choose the most effective option when indicating one therapeutic option over another.

Objective: To evaluate the postoperative analgesic effectiveness of meloxicam (7.5 mg) compared to ibuprofen (400 mg) in patients undergoing third molar(s) extraction.

Design: Randomized controlled clinical trial, double-masked, designed according to CONSORT guideline requirements.

Study Timeline

• Study First Submitted: 2024-07-05
• Status Verified: 2024-11
• Study First Submitted QC: 2024-11-22
• Last Update Submitted: 2024-11-22
• Study First Posted: 2024-11-25
• Last Update Posted: 2024-11-25
• Study Start: 2024-12-15
• Primary Completion: 2025-01-15
• Study Completion: 2025-01-20

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 68

Inclusion Criteria

Maxillary or mandibular third molar with semi or fully erupted crown.

Exclusion Criteria

Patients with Systemic pathologies. Presence of third molar localized infection. Completely included third molar crown. Periodontal compromise. Pregnant or breastfeeding women. Patients with hypersensitivity to NSAIDs. Patients with a history of drug abuse. Patients who had taken any drug in the previous 24 hours. Intervention (exodontia) time longer than 45 minutes.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A control. Ibuprofen	meloxicam 7,5mg	Ibuprofen 400mg tablets, 1 every 8 hours for 3 days will be administered for post-surgical pain.
Group B experimental. Meloxicam	meloxicam 7,5mg	Meloxicam 7.5mg tablets, 1 every 12 hours for 3 days will be administered for post-surgical pain.

Primary Outcome Measures

Name	Time	Method
Meloxicam effectiveness for post-surgical pain control.	3 days	A visual analogue scale ranging from 0 points (no pain) to 10 points (intolerable pain) will be used to measure post-exodontic pain, and values will be recorded on a questionnaire.