Effects of Repeated Transcranial Magnetic Stimulation (rTMS) on the Treatment of Cocaine Addicted Patients

Phase 2

• Conditions: Cocaine Addiction; Treatment; Transcranial Magnetic Stimilation
• Interventions: Procedure: Transcranial Magnetic Stimulation

• Registration Number: NCT01259362
• Lead Sponsor: University of Sao Paulo General Hospital

Brief Summary

Cocaine addiction is a serious disease. Nowadays we still have no efficient method reducing craving and extending the abstinence period of this patients during treatment.

The aim of this study is to evaluate reduction if craving and other parameters related to addiction within this group of patients through a treatment with transcranial magnetic stimulation.

Detailed Description

Patients are going to submitted do a course of rTMS of one month, each session up to 15 minutes.

After the rTMS they are going to be offered cognitive therapy to prevent relapse.

The area stimulated is the dorso-lateral prefrontal cortex. This technique was employed in previous studies and the risks are insignificant.

Study Timeline

• Study Start: 2010-03
• Status Verified: 2010-09
• Study First Submitted: 2010-12-10
• Study First Submitted QC: 2010-12-13
• Study First Posted: 2010-12-14
• Last Update Submitted: 2010-12-21
• Last Update Posted: 2010-12-22
• Primary Completion: 2012-03
• Study Completion: 2012-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Minimum age of 18
• Maximum age of 40
• Diagnostic of Cocaine addiction
• Willingly participate the study

Exclusion Criteria

• Metallic Cerebral Implant
• History of Severe Brain trauma or injury
• Organic Brain Disease
• Severe Somatic Disease
• History of other actual or past psychiatric diagnostics

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Transcranial Magnetic Stimulation	Transcranial Magnetic Stimulation	Cocaine addicted will receive a 20 day TMSr to right dorsolateral prefrontal cortex.
Transcranial Magnetic Stimlation	Transcranial Magnetic Stimulation	cocaine addicted will receive a 20 day sham TMSr to right dorsolateral prefrontal cortex

Primary Outcome Measures

Name	Time	Method
Minnesota Cocaine Craving Scale(MCCS)	2 months	Reduction on the scores of MCCS

Secondary Outcome Measures

Name	Time	Method
Barrat Impulsiveness Scale vers 11 ( BIS 11)	2 months	Reduction of scores of BIS 11.

Trial Locations

Locations (1)

Department and Institute of Psychiatry, General Hospital, University of Sao Paulo medical school; 🇧🇷 Sao Paulo, SP, Brazil