Study of Brain-spinal Cord Neural Connectivity in Spasticity
- Conditions
- Spasticity, Muscle
- Registration Number
- NCT06281223
- Lead Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Brief Summary
Little is known about the peripheral and central mechanisms of action of selective dorsal rhizotomy surgery for the treatment of spasticity. A better understanding of these mechanisms will enable us to improve the surgical procedure. This will require cortico-medullo-radiculo-muscular recordings never before performed and published in the literature, and the identification of variations in connectivity correlated with the clinic.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 50
- Patients aged 3 to 17 years included
- scheduled for selective rhizotomy surgery
- Having received informed consent to participate in the study (written consent from both parents)
- Affiliated or beneficiary of a social security scheme
- Contraindications to selective rhizotomy
- History of epilepsy
- Known neurological and/or psychiatric disorders with past and/or current medical treatment, or drug addiction
- Patient under legal protection
- Pregnant or breast-feeding women
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method variation in "spontaneous/resting" cortico-medullo-radiculo-muscular synchronization before and after selective rhizotomy surgery Day 0 variation in the mean spectral power of the neuronal signal between the brain, spinal cord, roots/radicles and muscles (simultaneous recording levels) before and after surgery.
Recordings are expressed as currents, themselves defined by waves. Calculating the average spectral power of the neuronal signal at several points is equivalent to quantifying the power of similarity (frequency and amplitude) between two waves.
- Secondary Outcome Measures
Name Time Method