Study of Brain-spinal Cord Neural Connectivity in Spasticity
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- variation in "spontaneous/resting" cortico-medullo-radiculo-muscular synchronization before and after selective rhizotomy surgery
研究概览
简要总结
Little is known about the peripheral and central mechanisms of action of selective dorsal rhizotomy surgery for the treatment of spasticity. A better understanding of these mechanisms will enable us to improve the surgical procedure. This will require cortico-medullo-radiculo-muscular recordings never before performed and published in the literature, and the identification of variations in connectivity correlated with the clinic.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 3 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 3 to 17 years included
- •scheduled for selective rhizotomy surgery
- •Having received informed consent to participate in the study (written consent from both parents)
- •Affiliated or beneficiary of a social security scheme
排除标准
- •Contraindications to selective rhizotomy
- •History of epilepsy
- •Known neurological and/or psychiatric disorders with past and/or current medical treatment, or drug addiction
- •Patient under legal protection
- •Pregnant or breast-feeding women
结局指标
主要结局
variation in "spontaneous/resting" cortico-medullo-radiculo-muscular synchronization before and after selective rhizotomy surgery
时间窗: Day 0
variation in the mean spectral power of the neuronal signal between the brain, spinal cord, roots/radicles and muscles (simultaneous recording levels) before and after surgery. Recordings are expressed as currents, themselves defined by waves. Calculating the average spectral power of the neuronal signal at several points is equivalent to quantifying the power of similarity (frequency and amplitude) between two waves.
次要结局
未报告次要终点