Effects of neuromuscular stimulation on quadriceps in chronic obstructive pulmonary disease (COPD)
Not Applicable
Completed
- Conditions
- Respiratory disease (chronic obstructive pulmonary disease)RespiratoryRespiratory disease
- Registration Number
- ISRCTN87439020
- Lead Sponsor
- niversity Hospitals of Leicester NHS Trust (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
1. Diagnosis of COPD
2. Forced expiratory volume in one second (FEV1) less than 50% predicted
3. FEV1/forced vital capacity (FVC) ratio less than 70%
4. Medical Research Council (MRC) dyspnoea score greater than 3
5. Clinically stable at time of recruitment (greater than 4 weeks exacerbation free)
6. Aged greater than 40 years, both sexes
Exclusion Criteria
1. Uses long-term oral corticosteroids
2. Uses anticoagulation (e.g. warfarin)
3. Impaired clotting
4. Long-term oxygen therapy
5. Comorbid condition preventing exercise training, causing exercise limitation
6. Pulmonary rehabilitation in last 12 months
7. Condition causing intramuscular inflammation (e.g. type two diabetes [T2D], rheumatoid arthritis, inflammatory bowel disease)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Muscle Mass: quadriceps mass change at 6 weeks
- Secondary Outcome Measures
Name Time Method 1. Neural Adaptations to Training at 6 weeks <br>2. Muscle Architecture including pennation angle at 6 weeks <br>3. Muscle Morphology including fibre type at 6 weeks <br>4. Muscle hypertrophy including satellite cell activity and cross sectional area at 24 hours and 6 weeks <br>5. Acute local inflammation response at 24 hours and 6 weeks <br>6. Functional change in quadriceps strength at 6 weeks