The role of exercise in treatment of women with Polycystic Ovary Syndrome (PCOS): mechanisms of actio

Completed

• Conditions: Polycystic ovary syndrome; Nutritional, Metabolic, Endocrine; Ovarian dysfunction

• Registration Number: ISRCTN84763265
• Lead Sponsor: Southern Health (Australia)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-01-23
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 30

Inclusion Criteria

1. Overweight women (body mass index [BMI] greater than 27 kg/m^2)
2. Aged 18 - 40 years with PCOS and without
3. Diagnosed from a history of perimenarchal onset of irregular cycles (less than 21 days or greater than 35 days)
4. Clinical manifestations of hyperandrogenism (hirsutism, acne) or biochemical hyperandrogenism with elevation of at least one circulating ovarian androgen (1990 National Institute of Health [NIH] criteria)

Exclusion Criteria

1. BMI less than 27 kg/m^2
2. Other concurrent medical conditions
3. Ongoing use of the oral contraceptive pill (OCP)
4. Pregnancy or desire for pregnancy
5. Secondary causes of amenorrhoea and hyperandrogenism

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Effects on insulin resistance, measured at baseline and after 12 weeks of exercise.

Secondary Outcome Measures

Name	Time	Method
1. Clinical symptom improvement<br>2. Insulin signalling<br>3. Mitochondrial function<br><br>Measured at baseline and after 12 weeks of exercise.