High Light and Low Light Dose PDT in Glioma
- Conditions
- Brain and Central Nervous System Tumors
- Interventions
- Registration Number
- NCT00118222
- Lead Sponsor
- Case Comprehensive Cancer Center
- Brief Summary
RATIONALE: Photodynamic therapy uses a drug, such as porfimer sodium, that becomes active when it is exposed to a certain kind of light. When the drug is active, tumor cells are killed. Giving photodynamic therapy after surgery may kill any remaining tumor cells.
PURPOSE: This randomized clinical trial is studying two different light doses of photodynamic therapy using porfimer sodium to compare how well they work in treating patients who are undergoing surgery for recurrent malignant astrocytoma.
- Detailed Description
OBJECTIVES:
* Compare survival of patients undergoing surgical resection for recurrent high-grade malignant supratentorial astrocytoma treated with intraoperative high vs low light dose photodynamic therapy using porfimer sodium.
OUTLINE: This is a randomized, multicenter study. Patients are stratified according to participating center. Patients are randomized to 1 of 2 treatment arms.
All patients receive porfimer sodium IV. One day later, patients undergo craniotomy and tumor resection.
* Arm I: During surgery, patients receive low light dose photodynamic therapy.
* Arm II: During surgery, patients receive high light dose photodynamic therapy. After completion of study treatment, patients are followed at 1 day, 6 weeks, and 3 months and then every 3 months for up to 2 years.
PROJECTED ACCRUAL: Approximately 120 patients will be accrued for this study within 4-5 years.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Low light dose during surgery adjuvant therapy Arm I: During surgery, patients receive low light dose photodynamic therapy. Low light dose during surgery conventional surgery Arm I: During surgery, patients receive low light dose photodynamic therapy. High light dose during surgery adjuvant therapy Arm II: During surgery, patients receive high light dose photodynamic therapy. High light dose during surgery conventional surgery Arm II: During surgery, patients receive high light dose photodynamic therapy. Low light dose during surgery porfimer sodium Arm I: During surgery, patients receive low light dose photodynamic therapy. High light dose during surgery porfimer sodium Arm II: During surgery, patients receive high light dose photodynamic therapy.
- Primary Outcome Measures
Name Time Method Time to progression and survival measured at 4-6 weeks post-operatively and then every 3-4 months thereafter
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ireland Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center
🇺🇸Cleveland, Ohio, United States