The Predictive Scores for Gastric Cancer in Gastric Intestinal Metaplasia (GIM) Patient: a Recommendation for Thai Population
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Gastric Intestinal Metaplasia
- Sponsor
- King Chulalongkorn Memorial Hospital
- Enrollment
- 280
- Locations
- 1
- Primary Endpoint
- The prevalence of early gastric cancer in gastric intestinal metaplasia(GIM) patient from 5 year-follow-up in Thai population
- Last Updated
- 13 years ago
Overview
Brief Summary
The predictive scores for gastric cancer in gastric intestinal metaplasia(GIM) patient: a recommendation for Thai population.
Objective:
To evaluate major risk factors for gastric cancer in gastric intestinal metaplasia(GIM) patient in order to propose the appropriate recommendation for Thai people.
Research Design:
Single center, retrospective-cohort study.
Detailed Description
Study population and Sample size at Faculty of Medicine, Chulalongkorn University The patients who were diagnosed gastric intestinal metaplasia from 1997 to 2012 and then follow up for 5 years. Estimate sample size =280 * Investigational product, dosage \& route of administration * Questionnaire for explore the risk factors * EGD with biopsy * Blood sampling for gastro panel * Duration of participation * 5 years or until diagnose gastric cancer Statistical method: Unconditional-binary-logistic regression
Investigators
Rapat Pittayanon, MD
Principle investigator
King Chulalongkorn Memorial Hospital
Eligibility Criteria
Inclusion Criteria
- •All patients were diagnosed GIM
- •All patients have to sign the consent form
Exclusion Criteria
- •Previous gastric surgery including gastrectomy and bypass surgery
- •Bleeding tendency including decompensated cirrhosis, chronic kidney disease and long-tem antiplatelets or anticoagulants
- •HIV infection
- •History of proton pump inhibitor use within 1 week
- •History of antibiotic use within 4 weeks
Outcomes
Primary Outcomes
The prevalence of early gastric cancer in gastric intestinal metaplasia(GIM) patient from 5 year-follow-up in Thai population
Time Frame: Up to 5 years
In Thailand, gastric cancer patients usually presented with advance stage and carried the dismal prognosis. GIM is a well known precancerous lesion. The appropriate follow-up period in high risk GIM patient can increase the prevalence of early gastric cancer and reduce the mortality rate of gastric cancer