Study of Fibrinogen Metabolism During Severe Trauma and Burns
Completed
- Conditions
- Burn InjuryMajor Trauma
- Registration Number
- NCT00588796
- Lead Sponsor
- United States Army Institute of Surgical Research
- Brief Summary
To study the fibrinogen metabolic changes in relation to coagulation disorder in patients with severe burns and trauma injuries. As a result of the burn or trauma injury breakdown of fibrinogen is accelerated.
- Detailed Description
In this protocol, we will investigate fibrinogen metabolism in burn and trauma patients, using an 8h infusion of stable isotopes labeled amino acids (1-13C-phenylalanine, 2H5-phenylalanine, and 2H3-ketoisocaporate). The increase of the labeled amino acids incorporating into fibrinogen during the infusion and the decay of labeled fibrinogen after stopping the isotopes infusion (as measured by GC-MS) will be used to calculate fibrinogen synthesis and degradation. Stable isotopes are non-radioactive.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- 20% total body surface area burn or more
- severe trauma with injury severity score greater than 10
- between ages of 18 and 65 years
Exclusion Criteria
- history of blood clotting disorder
- history of liver disease such as cirrhosis or hepatitis
- pregnant or nursing
- allergic to iodine, shellfish or dye used in X-Rays
- taking long term medications for blood clotting usch as Coumadin or Plavix
- prisoners
- receiving total parenteral nutrition
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method During the flow phase following burn or trauma injury, fibrinogen degradation is accelerated 7
- Secondary Outcome Measures
Name Time Method Fibrinogen degradation stimulates fibrinogen synthesis at the expense of whole body protein catabolism 7 days