A Multicenter, Retrospective Study to Evaluate the Efficacy of Systemic Gluco-corticoid Against COVID-19
Not Applicable
- Conditions
- ovel Coronavirus Infections (COVID-19)
- Registration Number
- JPRN-UMIN000040211
- Lead Sponsor
- Kanagawa Cardiovascular and Respiratory Center
- Brief Summary
The odds of improvement in a 7-point ordinal score on Day 15 was significantly lower for the corticosteroid versus non-corticosteroid group. The time to improvement in radiological findings was significantly shorter in the corticosteroid. The duration of invasive mechanical ventilation was shorter in corticosteroid group. Of the 106 patients who received methylprednisolone, the duration of invasive mechanical ventilation was significantly shorter in the pulse/semi-pulse group.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 1092
Inclusion Criteria
Not provided
Exclusion Criteria
1)Requiring home oxygen therapy prior to having COVID-19
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The odds ratio for improvement on a 7-point ordinal scale* on Day 15. [*The scale is as follows: 1) Death, 2) Hospitalized, on invasive mechanical ventilation or Extracorporeal Membrane Oxygenation (ECMO), 3) Hospitalized, on non-invasive ventilation or high flow oxygen devices, 4) Hospitalized, requiring low flow supplemental oxygen, 5) Hospitalized, not requiring supplemental oxygen - requiring ongoing medical care (COVID-19 related or otherwise), 6) Hospitalized, not requiring supplemental oxygen - no longer required ongoing medical care, 7) Not hospitalized.]
- Secondary Outcome Measures
Name Time Method 1)Time to PCR negativity of the swab solution 2)Duration of heat generation 3)Percentage of improvement in imaging findings 4)Period of time until improvement in imaging findings is confirmed 5)Percentage needed/ period of time until needed/period of implementation of supplemental oxygen/ Ventilation/ECMO 6)Period of hospitalization 7)Survival period.