Porphyromonas Gingivalis and Alzheimer's Disease

Completed

• Conditions: Dementia; Alzheimer's Disease; Periodontitis

• Registration Number: NCT02109705
• Lead Sponsor: University Hospital Muenster

Brief Summary

With this study the investigators would like to analyze the the role of periodontal disease and especially the role of Porphyromonas gingivalis in initiation and progression of Alzheimer's Disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-03
• Study First Submitted: 2014-03-31
• Study First Submitted QC: 2014-04-07
• Study First Posted: 2014-04-10
• Status Verified: 2014-12
• Primary Completion: 2021-01
• Study Completion: 2021-01
• Last Update Submitted: 2023-05-30
• Last Update Posted: 2023-05-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• age 40-70
• caucasian origin
• dementia (Alzheimer's or other dementia)
• cognitive healthy (need for spinal anesthesia)

Exclusion Criteria

• use of antibiotics within las 6 months
• pregnancy
• another illness explaining the symptoms in a better way
• smoking (>10 cigarettes)
• patients who have a legal custodian

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cmax Antibody Levels against Gingipains	Baseline	laboratory analysis

Secondary Outcome Measures

Name	Time	Method
Cmax Beta-Amyloid	Baseline	laboratory analysis

Trial Locations

Locations (1)

Department of Periodontology; 🇩🇪 Muenster, Germany