Humoral immune deficiency in bronchiectasis

Not Applicable

Recruiting

• Conditions: Diseases of th respiratory system

• Registration Number: KCT0005220
• Lead Sponsor: Yonsei University, Wonju Severance Christian Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 6 January 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Patient (bronchiectasis)
- Adults = 20 years
- Presence of past history of bronchiectasis exacerbation or pneumonia
(Bronchiectasis exacerbation is defined as an aggravation of respiratory symptoms, such as cough, amount or viscosity of sputum, hemoptysis, and dyspnea, for which additional treatment is necessary.
- Absence of past history of pneumococcal vaccination or 5 years later since pneumococcal vaccination

Healthy controls
- Adults without bronchiectasis
- Asymptomatic patients present with simple benign lung nodule
- Not being treated for chronic liver, kidney, lung or cancer
- Including subjects who do not meet the indication of pneumococcal vaccination

Exclusion Criteria

- Uncontrolled asthma, COPD
- Current treatment for active tuberculosis, lung cancer or interstitial lung disease
- Current treatment for bronchiectasis exacerbation
- Pregnancy

Study & Design

• Study Type: Observational Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Comparison of proportion of IgGSD and SAD between patients with bronchiectasis and healthy controls.

Secondary Outcome Measures

Name	Time	Method
Analysis of sputum cytokine in patients with humoral immune deficiency in comparison to those without humoral immune deficiency;Analysis of clinical characteristics of patients with humoral immune deficiency in comparison to those without humoral immune deficiency