Prostate Cancer Prospective Cohort
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 1,937
- 试验地点
- 1
- 主要终点
- Ability to recognize increased risk of metastatic prostate cancer based on specific genetic polymorphisms.
研究概览
简要总结
The overall purpose of this research is to determine if certain genes increase the chance of developing prostate cancer and once diagnosed increase the chance of the prostate cancer spreading to other parts of the body.
详细描述
DNA will be isolated from each person and then studied for the presence of certain genes that may increase the chance of developing prostate cancer. Certain genes will also be studied in patients with known prostate cancer to determine if they increase the chance of cancer spreading to other parts of the body and decrease one's chance of being cured. Small differences in genes can slightly affect their ability to function. While these differences are normal, they may influence the way the cancer responds to therapy. An understanding of which genes increase (or decrease) the chance of being cured of a disease, such as prostate cancer, will improve our ability to take care of patients more effectively.
A second purpose of this study is to collect blood and cancer tissue for future studies. While the small differences in genes may be the best marker of bad cancer, it is also possible that proteins in blood or tumor may be a better marker.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Newly diagnosed patients:
- •newly diagnosis of prostate cancer
- •untreated except for neoadjuvant systemic therapy.
排除标准
- •Newly diagnosed patients:
- •inability to give informed consent
结局指标
主要结局
Ability to recognize increased risk of metastatic prostate cancer based on specific genetic polymorphisms.
时间窗: At the time of prostate cancer diagnosis
次要结局
- Ability to predict risk for treatment failure based on analysis of specific polymorphisms.(At the time of prostate cancer diagnosis)