Buprenorphine in the Emergency Department: Buprenorphine Versus Clonidine for Opioid Withdrawal
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 26
- 主要终点
- Number of participants attending the rapid access clinic
研究概览
简要总结
This is a pilot randomized control trial randomizing patients presenting in opioid withdrawal to the emergency department to receive either one of clonidine (usual standard of care) or buprenorphine for their opioid withdrawal. Primary treatment outcome is attendance at a rapid access addiction medicine clinic within a few days of emergency room presentation. Secondary treatment outcome is treatment status with respect to opioid agonist treatment at one month post emergency room visit.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presenting to the ED in opioid withdrawal or soon to be in withdrawal
- •Minimum age 16
- •English speaking
- •Active phone number
- •Ontario Health Insurance Program card
排除标准
- •Currently enrolled in a methadone or buprenorphine maintenance
- •Benzodiazepine addiction (or taking >50mg of valium equivalent/day)
- •Acute hepatitis or liver failure
研究组 & 干预措施
Buprenorphine
Patient receives buprenorphine in the emergency room based on a clinical trial protocol as well as a take home prescription for buprenorphine
干预措施: Buprenorphine (Drug)
Clonidine
Patient receives clonidine in the emergency room based on a clinical trial protocol and also receives a take home prescription for clonidine
干预措施: Clonidine (Drug)
结局指标
主要结局
Number of participants attending the rapid access clinic
时间窗: 2-5 days
The number of participants who attend a rapid access clinic assessment after initial enrollment
次要结局
- Number of participants who are on opioid agonist treatment(30 days)
研究者
Anita Srivastava
Staff Physician and Associate Professor
St. Joseph's Health Centre Toronto