Confocal lAser EndomicroScopy in patients with non-resolving Acute Respiratory failure

Recruiting

• Conditions: acute respiratory distress syndrome; non resolving acute respiratory insufficiency in mechanically ventilated patients; 10024967

• Registration Number: NL-OMON51162
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

- *18 years of age
- Non-resolving acute respiratory failure mandating a standard
diagnostic bronchoscopy with broncho-alveolar lavage

Exclusion Criteria

- Inability and willingness to provide informed consent by family-members
-ECMO
- Inability to comply with the study protocol

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>identification of specific CLE patterns of the alveolar compartment of COVID 19<br /><br>invasivally ventilated patients</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-Description of how CLE patterns change over time within the same patients<br /><br>- Descriptive correlation of CLE patterns with Chest CT<br /><br>- Descriptive correlation of CLE patterns with lung ultrasound<br /><br>- Descriptive correlation of CLE patterns with cytology from bronchoalveolar<br /><br>lavage<br /><br>-Descriptive correlation of in vivo CLE patterns with histology (when available)<br /><br>-Descriptive correlation of ex vivo CLE images with histology (when available)<br /><br>-Time of procedure<br /><br>- Proportion of successful imaging of alveolar compartment</p><br>