Etiologic, Pathophysiologic, and Genetic Classification of Heart Failure With Preserved Ejection Fraction
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure With Preserved Ejection Fraction
- Sponsor
- Northwestern University
- Enrollment
- 514
- Locations
- 1
- Primary Endpoint
- Cardiovascular hospitalization
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of this study is to create a classification system for the heterogenous disorder of heart failure with preserved ejection fraction (HFpEF).
Detailed Description
Patients with HFpEF are a heterogeneous group with varying etiology and pathophysiology, which may play a large role in the difficulty in managing these patients and enrolling them in clinical trials. A major advance in the care of patients with HFpEF would be a classification system based on etiology, pathophysiology, and/or genetic factors as well as machine learning analyses. The ultimate goal of this study is to demonstrate that it is possible to better classify patients with HFpEF based on etiologic, pathophysiologic, and genetic differences between patients. If successful, this study could lead to: (1) novel risk estimation in patients with HFpEF and (2) more fruitful clinical trials based on targeting specific subsets of HFpEF.
Investigators
Sanjiv Shah
Associate Professor of Medicine
Northwestern University
Eligibility Criteria
Inclusion Criteria
- •Age \> 21 years
- •Signs or symptoms of congestive heart failure
- •Left ventricular ejection fraction \> 50%
Exclusion Criteria
- •Severe valvular heart disease
- •History of cardiac transplantation
- •Prior history of heart failure associated with left ventricular ejection fraction \< 35%
Outcomes
Primary Outcomes
Cardiovascular hospitalization
Time Frame: 1 year
Mortality - all cause and cardiovascular
Time Frame: 1 year
Heart failure hospitalization
Time Frame: 1 year
Secondary Outcomes
- Exercise capacity (peak VO2)(1 year)