hCAP18 Levels and Vitamin D Deficiency in Healthy Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 99
- 试验地点
- 1
- 主要终点
- Baseline 25-OH Vitamin D Level
研究概览
简要总结
Vitamin D deficiency (low levels of vitamin D in the blood) is a common problem. A recently discovered protein, called hCAP18, likely plays an important role in the immune system and may depend on adequate levels of vitamin D. It is not known what levels of vitamin D are needed to allow the body to make this protein. Nor is it known if giving vitamin D to people who are found to be deficient will help boost levels of hCAP18. This study aims to clarify the relationship between vitamin D levels and hCAP18.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-80
排除标准
- •Known active infectious disease or chronic inflammatory disorder
- •Hypercalcemia
- •Chronic kidney disease
- •Pregnancy
研究组 & 干预措施
1
Vitamin D insufficient (treated with ergocalciferol 50,000 IU every other day x 5 doses)
干预措施: ergocalciferol (Drug)
结局指标
主要结局
Baseline 25-OH Vitamin D Level
时间窗: Baseline
hCAP18 Levels
时间窗: Baseline
次要结局
未报告次要终点
研究者
Ishir Bhan, MD, MPH
Instructor in Medicine
Massachusetts General Hospital