hCAP18 Levels and Vitamin D Deficiency in Healthy Subjects

Not Applicable

Completed

• Conditions: Healthy Subjects; Vitamin D Deficiency
• Interventions: Drug: ergocalciferol

• Registration Number: NCT00742235
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

Vitamin D deficiency (low levels of vitamin D in the blood) is a common problem. A recently discovered protein, called hCAP18, likely plays an important role in the immune system and may depend on adequate levels of vitamin D. It is not known what levels of vitamin D are needed to allow the body to make this protein. Nor is it known if giving vitamin D to people who are found to be deficient will help boost levels of hCAP18. This study aims to clarify the relationship between vitamin D levels and hCAP18.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-07
• Study First Submitted: 2008-08-25
• Study First Submitted QC: 2008-08-25
• Study First Posted: 2008-08-27
• Primary Completion: 2012-01
• Study Completion: 2012-01
• Results First Submitted: 2013-06-05
• Results First Submitted QC: 2013-09-09
• Results First Posted: 2013-11-11
• Status Verified: 2016-03
• Last Update Submitted: 2016-03-15
• Last Update Posted: 2016-04-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 99

Inclusion Criteria

• Age 18-80

Exclusion Criteria

• Known active infectious disease or chronic inflammatory disorder
• Hypercalcemia
• Chronic kidney disease
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	ergocalciferol	Vitamin D insufficient (treated with ergocalciferol 50,000 IU every other day x 5 doses)

Primary Outcome Measures

Name	Time	Method
Baseline 25-OH Vitamin D Level	Baseline
hCAP18 Levels	Baseline

Trial Locations

Locations (1)

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States